The transcriptional coactivators p300 and CBP are histone acetyltransferases.
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Summary
It is demonstrated that p300/CBP acetylates nucleosomes in concert with PCAF, a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyl transferases.
- Type
- article
- Published
- 1996-11-29
- Cited by
- 3,058
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985063313
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2624456
Keywords
PCAF, Histone Acetyltransferases, P300-CBP Transcription Factors, Histone acetyltransferase, Biology
References
- Role of CBP/P300 in nuclear receptor signalling
- The assembly of regularly spaced nucleosomes in the Xenopus oocyte S-150 extract is accompanied by deacetylation of histone H4.
- Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.
- Interaction of the co‐activator CBP with Myb proteins: effects on Myb‐specific transactivation and on the cooperativity with NF‐M.
- The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300
- Phosphorylation of the adenovirus E1A‐associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.
- Nuclear protein CBP is a coactivator for the transcription factor CREB
- Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
- Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
- RGFGIGS Is an Amino Acid Sequence Required for Acetyl Coenzyme A Binding and Activity of Human Spermidine/Spermine N1Acetyltransferase*
- Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation.
- The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins.
- Targeting chromatin disruption: Transcription regulators that acetylate histones.
- Decoding the nucleosome.
- Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment.
- Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.
- Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.
- Nucleosome positioning and modification: chromatin structures that potentiate transcription.
- A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
- Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
Cited by
- Functional analysis of human enhancers using the zebrafish embryo
- Purification and biochemical properties of the Drosophila TAC1 complex.
- Histone acetylation: chromatin in action.
- Conjunction dysfunction: CBP/p300 in human disease.
- The Immunoglobulin Heavy Chain Locus Control Region Increases Histone Acetylation along Linked c-myc Genes
- Tip60 Is a Nuclear Hormone Receptor Coactivator*
- Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.
- THE AML1‐ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE
- Ligand‐induced recruitment of a histone deacetylase in the negative‐feedback regulation of the thyrotropin β gene
- Characterization of Receptor-interacting Protein 140 in Retinoid Receptor Activities*
- PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner
- Histone acetylases—versatile players
- The Histone Acetyltransferase Domains of CREB-binding Protein (CBP) and p300/CBP-associated Factor Are Not Necessary for Cooperativity with the Class II Transactivator*
- Cooperative Coactivation of Estrogen Receptor α in ZR-75 Human Breast Cancer Cells by SNURF and TATA-binding Protein*
- A POP‐1 repressor complex restricts inappropriate cell type‐specific gene transcription during Caenorhabditis elegans embryogenesis
- Chromatin structure and gene regulation in the immune system.
- EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response*
- Molecular studies in 10 cases of Rubinstein-Taybi syndrome, including a mild variant showing a missense mutation in codon 1175 of CREBBP
- Acetyllysine-binding and function of bromodomain-containing proteins in chromatin.
- Regulation of cell growth and expression of 7B2, PC2, and PC1/3 by TGFβ 1 and sodium butyrate in a human pituitary cell line (HP75)
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