Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Explore this paper's citation graph
Summary
The results suggest that TH17 cells, through the production of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis.
- Type
- article
- Published
- 2007-02-08
- Cited by
- 2,011
- References
- 31
- OpenAlex
- https://openalex.org/W2012077729
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4377044
Keywords
Acanthosis, Cytokine, Psoriasis, Interleukin 20, Interleukin 17
References
- IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes1
- A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R1
- IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues.
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
- Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation
- IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
- Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.
- IL-22 increases the innate immunity of tissues.
- A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis.
- Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40.
- Interleukin-1 induces transcription of keratin K6 in human epidermal keratinocytes.
- Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16.
- Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities.
- T cells involved in psoriasis vulgaris belong to the Th1 subset.
- Understanding the IL-23-IL-17 immune pathway.
- Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
- Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
- TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
- Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).
- IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
Cited by
- Wolbachia endosymbiont of Onchocerca volvulus: driver of immunopathology and target for therapy
- Th17 T cells: linking innate and adaptive immunity.
- Antimicrobial peptides and self-DNA in autoimmune skin inflammation.
- Psoriatic skin lesions induced by BCG vaccination.
- Epicutaneous sensitization with a protein antigen induces Th17 cells.
- ESAT‐6‐ and CFP‐10‐Specific Th1, Th22 and Th17 Cells in Tuberculous Pleurisy May Contribute to the Local Immune Response Against Mycobacterium Tuberculosis Infection
- Angiogenic and Inflammatory Properties of Psoriatic Arthritis
- New pathogenic and therapeutic paradigms in atopic dermatitis.
- IκBζ is a key driver in the development of psoriasis
- IL-22 regulation of functional gene expression in salivary gland cells
- Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm.
- Retinoic acid regulates immune responses by promoting IL-22 and modulating S100 proteins in viral hepatitis
- Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease.
- An Interleukin‐25‐Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation
- IL‐22 sustains epithelial integrity in progressive kidney remodeling and fibrosis
- Phase 2, randomized dose‐finding study of tapinarof (GSK2894512 cream) for the treatment of plaque psoriasis
- Interleukin-22 regulates interferon lambda expression in a mice model of pseudomonas aeruginosa pneumonia.
- Therapeutic Effects of Shikonin on Skin Diseases: A Review.
- Génération et analyse fonctionnelle d'antagonistes de l'oncostatine m et de l'interleukine-31, cytokines impliquées dans l'inflammation cutanée et le développement tumoral
- The influence of biologic therapy on the capacity of regulatory T cells to restrain Th17 responses
Related papers
- Gross and histopathological characteristics of fibropapilloma in camels (Camelus dromedarius)
- AIDS complicated with malignant syphillis:a case report
- 437 IL-17C inhibition reduces skin inflammation in IL23-induced psoriasis mouse model
- Interleukin-17A Drives IL-19 and IL-24 Expression in Skin Stromal Cells Regulating Keratinocyte Proliferation
- Out of the shadow of interleukin-17A: the role of interleukin-17F and other interleukin-17 family cytokines in spondyloarthritis
- The Th17 cytokine IL‐22 induces IL‐20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis
- Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses