T cells involved in psoriasis vulgaris belong to the Th1 subset.
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Summary
In vivo and in vitro cytokine secretion patterns of T lymphocytes from psoriatic lesions indicate that T cells involved in psoriasis exhibit a Th1-like cytokine gland secretion profile.
- Type
- article
- Published
- 1994-02-01
- Cited by
- 471
- References
- 39
- OpenAlex
- https://openalex.org/W2049702967
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33812063
Keywords
Cytokine, CD8, Biology, Tumor necrosis factor alpha, T cell
References
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- IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.
- Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
- Systemic TNF administration in psoriatic patients: a promising therapeutic modality for severe psoriasis
- Slow bacterial infections or autoimmunity?
- Reversal by interferon‐γ of inhibition of delay ed‐type hypersensitivity induction by anti‐CD4 or antiinterleukin 2 receptor (CD25) monoclonal antibodies. Evidence for the physiological role of the CD4+ TH1+ subset in mice
- Detection of interferon-gamma mRNA in psoriatic epidermis by polymerase chain reaction.
- Th1 lymphokine production profiles of nickel-specific CD4+T-lymphocyte clones from nickel contact allergic and non-allergic individuals.
- Immunologic mechanisms in psoriasis.
- Localization of neutrophil-activating peptide-1/interleukin-8-immunoreactivity in normal and psoriatic skin.
- Cytokine-induced expression of transforming growth factor-alpha and the epidermal growth factor receptor in neonatal skin explants.
- Cytokines in skin lesions of psoriasis.
- Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis.
- Analysis of the in vitro cytokine production by liver‐infiltrating T cells of patients with autoimmune hepatitis
- Upper keratinocytes of psoriatic skin lesions express high levels of NAP-1/IL-8 mRNA in situ.
Cited by
- Avances en el tratamiento de la psoriasis
- A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases.
- Interleukin-10 in cutaneous disorders: implications for its pathophysiological importance and therapeutic use
- Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.
- Psoriasis is associated with lipid abnormalities at the onset of skin disease.
- Mast Cell-Mediated and Associated Disorders in Pregnancy: A Risky Game with an Uncertain Outcome?
- Lesional psoriatic T cells contain the capacity to induce a T cell activation molecule CDw60 on normal keratinocytes.
- IL-1 Receptor Antagonist-Deficient Mice
- Cutaneous lymphocyte localization in the pathogenesis of psoriasis.
- Tratamiento de psoriasis con inhibidores del factor de necrosis tumoral-α: estudio de los mecanismos de acción
- Clinical and synovial tissue studies in psoriatic arthritis
- Clinical Utility of 1,25-Dihydroxyvitamin D 3 and Its Analogs for the Treatment of Psoriasis and Other Skin Diseases
- Increased expression of interleukin-4 receptors on psoriatic epidermal cells.
- Development of a bioengineered skin-humanized mouse model for psoriasis: dissecting epidermal-lymphocyte interacting pathways.
- The Frequency of Type 2 CD8+ T Cells Is Increased in Peripheral Blood from Patients with Psoriasis Vulgaris
- Cytokines, chemokines and their therapeutic manipulation in psoriasis.
- Function of psoriasis susceptibility gene CCHCR1
- Natural killer and natural killer-T cells in psoriasis
- Interleukin‐1 from epithelial cells fosters T cell‐dependent skin inflammation
- T Cell-Regulated Neutrophilic Inflammation in Autoinflammatory Diseases1
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