p53, guardian of the genome

Keywords

Guardian, Genome, Computational biology, Biology, Genetics

References

• Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53‐mediated growth arrest.Yaacov Barak, Moshe Oren — 1992
• Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.Farideh Z. Bischoff, Sun O. Yim, Sen Pathak — 1990
• Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.S. Fakharzadeh, Stephen P. Trusko, Donna L. George — 1991
• Participation of p53 protein in the cellular response to DNA damage.Michael B. Kastan, Onyinye Onyekwere, D Sidransky — 1991
• Mammalian p53 can function as a transcription factor in yeast.Richard Iggo, E. Schärer — 1992
• Identification of p53 as a sequence-specific DNA-binding proteinScott E. Kern, Kenneth W. Kinzler, Arthur M. Bruskin — 1991
• p53 mutations in human cancers.Monica Hollstein, David Sidransky, Bert Vogelstein — 1991
• Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication.Jill Bargonetti, Paula N. Friedman, Scott E. Kern — 1991
• Presence of a potent transcription activating sequence in the p53 protein.Stanley Fields, Sung Key Jang — 1990
• Inhibition of p53 transactivation required for transformation by adenovirus early 1B proteinP. Renée Yew, Arnold Berk — 1992
• Wild-type p53 activates transcription in vitroGeorge E. Farmer, Jill Bargonetti, Hua Zhu — 1992
• Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6Elisheva Yonish-Rouach, Dalia Resnftzky, Joseph Lotem — 1991
• Definition of a consensus binding site for p53Wafik S. El‐Deiry, Scott E. Kern, Jennifer A. Pietenpol — 1992
• Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene.Loretta Raycroft, Hongyun Wu, Guillermina Lozano — 1990
• Amplification of a gene encoding a p53-associated protein in human sarcomasJonathan D. Oliner, Kenneth W. Kinzler, Paul S. Meltzer — 1992
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.Jamil Momand, Gerard P. Zambetti, David C. Olson — 1992
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursLawrence A. Donehower, Michele Harvey, Betty L. Slagle — 1992
• UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cellsWarren Maltzman, Linda Czyzyk — 1984

Cited by

• Suppression of ras oncogene-mediated transformation.Reinhold Schäfer — 1994
• Genetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implications.S. Smith Justin — 2000
• Microallelotyping defines the sequence and tempo of alleiic losses at tumour suppressor gene loci during colorectal cancer progressionHerbert G. Schlicker, Richard Deacon, N. H. Twelker — 1995
• Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis?Lynn E. Davis, Debra Knopman — 1993
• Apoptosis: molecular mechanisms and implications for human diseaseStéphanie Durand — 1995
• p53 protein in low-grade astrocytomas: a study with long-term follow-up.Silvia Spiandore — 1994
• THE P53 TUMOUR SUPPRESSOR GENE AND TUMOUR PROGNOSIS : IS THERE A RELATIONSHIP ?Honor Croome — 1995
• Prognostic significance of p53 expression, chromosome 17 copy number, and DNA ploidy in non-metastasized colorectal carcinomas (stages IB and II).Ilkka Karanta, Antti Pesonen, Lauri Seitsonen — 1996
• Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigenAlexander Horz — 1996
• Lymphocyte death, p53, and the problem of the "undead" cell.David J. Harrison, Sarah Howie, A H Wyllie — 1995
• The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line.Fen Xia, Howard L. Liber — 1997
• Human p53 Binds Holliday Junctions Strongly and Facilitates Their Cleavage*Donald Leskiw — 1997
• Dynamics of Cell Cycle Regulators: Artefact-Free Analysis by Recultivation of Cells Synchronized by Centrifugal Elutriation順子 水林 — 1997
• Induction of c-fos Proto-oncogene in Mesangial Cells by Cadmium*Ian Hancock — 1998
• Bcl-2 expression in childhood leukemias: could it be used as a prognostic factor?Pablo Blanco Sarto — 1998
• The influence of p53 and associated factors on the outcome of patients with oral squamous cell carcinomaElizabeth Baraban, Lucie McCoy, Paul Simon — 1998
• Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc延幸 柴田, 直秀 富田 — 1999
• The effects of N-methyl-N-nitrosourea and azoxymethane on focal cerebral infarction and the expression of p53, p21 proteins.Santiago Soldevila Fragoso — 2000
• Molecular Genetic Parameters in Pathogenesis and Prognosis of Testicular Germ Cell TumorsJänos Bognár, Olga Jellinek — 2000
• Regulation of transcription factors by protein degradationJoana Desterro, Manuel S. Rodríguez, Ronald T. Hay — 2000

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