Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2
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Summary
A potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes is demonstrated and selective neuronal and muscle expression of daf-2(+) restored hypoxic death and prevented hypoxia-induced muscle and neuronal cell death.
- Type
- article
- Published
- 2002-06-13
- Cited by
- 266
- References
- 23
- OpenAlex
- https://openalex.org/W2011912518
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33410372
Keywords
Biology, Transcription factor, Cell biology, Caenorhabditis elegans, Programmed cell death
References
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- C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
- The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
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- Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
- Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate.
- A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
- Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.
- Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span.
Cited by
- Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.
- Insulin/insulin-like growth factor signaling in C. elegans.
- Gene regulatory mechanisms controlling ageing in Caenorhabditis elegans
- Necrotic cell death in Caenorhabditis elegans.
- Genome-wide analyses of expression data and HIF-1 binding sites provide insights to the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans
- Genetic Analysis of Development and Behavior in Hypoxia and Cellular Characterization of Anoxia Induced Meiotic Prophase Arrest in Caenorhabditis Elegans
- Aging Is a Determinant in Anoxia Stress Tolerance in Caenorhabditis Elegans
- インスリン/IGF様シグナルによる線虫の成長と老化、ストレス応答の制御
- Control of body size in C. elegans dependent on food and insulin/IGF‐1 signal
- Hypoxia-inducible regulatory networks and their roles in aging in C. elegans
- Characterization of Carbonic Anhydrases in Models of Neuronal Differentiation and in the Nematode Caenorhabditis elegans
- The ecological genetics of senescence and stress resistance in Caenorhabditis elegans
- The regulation of hypoxia-inducible factor (HIF-1) and the role of HIF-1 in C. elegans longevity
- Regulation of aging and innate immunity in C. elegans
- Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury
- Rôle des protéines 14-3-3 dans la régulation de la longévité par la voie DAF-2/Insuline/IGF-1 chez Caenorhabditis elegans
- Ceramides – Friend or Foe in Hypoxia?
- HIF-1 modulates longevity and healthspan in a temperature-dependent manner
- FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function
- The disruption of proteostasis in neurodegenerative disorders
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