HIF-1 modulates longevity and healthspan in a temperature-dependent manner

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Summary

It is found that stabilization of HIF‐1 increases life span robustly under all conditions tested; however, deletion of hif‐1 decreases life span in a temperature‐dependent manner and impairs healthspan at lower temperatures because of an age‐dependent loss of vulval integrity.

Type
article
Published
2011-02-23
Cited by
106
References
48
Access
Open access

Keywords

Longevity, Biology, Gene knockdown, Caenorhabditis elegans, Life span

References

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