HIF-1 modulates longevity and healthspan in a temperature-dependent manner
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Summary
It is found that stabilization of HIF‐1 increases life span robustly under all conditions tested; however, deletion of hif‐1 decreases life span in a temperature‐dependent manner and impairs healthspan at lower temperatures because of an age‐dependent loss of vulval integrity.
- Type
- article
- Published
- 2011-02-23
- Cited by
- 106
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W1662930619
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29818588
Keywords
Longevity, Biology, Gene knockdown, Caenorhabditis elegans, Life span
References
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- The FoxO code
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- Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes.
- Worming pathways to and from DAF-16/FOXO.
- Divergent Mechanisms Controlling Hypoxic Sensitivity and Lifespan by the DAF-2/Insulin/IGF-Receptor Pathway
- Oxidative stress and HIF-1 alpha modulate hypoxic ventilatory responses after hypoxic training on athletes.
Cited by
- Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
- Why Is Aging Conserved and What Can We Do about It?
- Genome-wide analyses of expression data and HIF-1 binding sites provide insights to the HIF-1 hypoxia-inducible factor in Caenorhabditis elegans
- Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection
- The Red Death Meets the Abdominal Bristle: Polygenic Mutation for Susceptibility to a Bacterial Pathogen in Caenorhabditis elegans
- Increased hypoxia-inducible factor 1alpha expression in rat brain tissues in response to aging
- Effects of pharmaceutical modulation of protein aggregation on lifespan in Caenorhabditis elegans
- The Mitoscriptome in Aging and Disease
- Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
- Oxidative stress and vascular inflammation in aging.
- The MDT-15 Subunit of Mediator Interacts with Dietary Restriction to Modulate Longevity and Fluoranthene Toxicity in Caenorhabditis elegans
- Being cool: how body temperature influences ageing and longevity
- Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in Caenorhabditis elegans
- Expression of Lymphocyte-derived Growth Hormone (GH) and GH-releasing Hormone Receptors in Aging Rats
- Longevity GWAS Using the Drosophila Genetic Reference Panel
- Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans
- UV-Photoconversion of Ethosuximide from a Longevity-Promoting Compound to a Potent Toxin
- Trinations aging symposium.
- mTOR is a key modulator of ageing and age-related disease
- Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
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