Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

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Summary

It is demonstrated that the histone deacetylase (HDAC) inhibitor drug trichostatin A (TSA) reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates disability in the relapsing phase of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS).

Type
article
Published
2005-07-01
Cited by
278
References
58

Keywords

Trichostatin A, Experimental autoimmune encephalomyelitis, Histone deacetylase, Histone deacetylase inhibitor, Neurodegeneration

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