Development of histone deacetylase inhibitors for cancer treatment
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Summary
Emerging evidence suggests that the effects of HDAC inhibitors on tumor cells may not only depend on the specificity and selectivity of the HDAC inhibitor, but also on the expression patterns ofHDAC enzymes in the tumor tissue.
- Type
- article
- Published
- 2007-04-01
- Cited by
- 154
- References
- 226
- OpenAlex
- https://openalex.org/W17428177
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5746706
Keywords
Constitutionalism, Wake, Government (linguistics), Transition (genetics), Political science
References
- Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
- Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
- Coordinated Changes in DNA Methylation and Histone Modifications Regulate Silencing/Derepression of Luteinizing Hormone Receptor Gene Transcription
- HDAC4: a corepressor controlling bone development.
- Fusion between a novel Krüppel‐like zinc finger gene and the retinoic acid receptor‐alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.
- Inhibitors of histone deacetylases as anti-inflammatory drugs.
- The fundamental role of epigenetic events in cancer
- Histone deacetylase interacts directly with DNA topoisomerase II
- Histone acetylation in chromatin structure and transcription
- Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis.
- DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
- Role of the histone deacetylase complex in acute promyelocytic leukaemia
- Molecular and cellular basis for the anti-proliferative effects of the HDAC inhibitor LAQ824.
- P21-dependent G 1 arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
- Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation.
- Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
- Regulation of microglial inflammatory response by histone deacetylase inhibitors
- The HDAC complex and cytoskeleton.
- The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.
- Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
Cited by
- Oxidative Stress by Targeted Agents Promotes Cytotoxicity in Hematologic Malignancies
- Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells
- A novel histone deacetylase inhibitor Chidamide induces apoptosis of human colon cancer cells.
- Epigenomics and ovarian carcinoma
- Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo.
- Genetically encoding thioacetyl‐lysine as a non‐deacetylatable analog of lysine acetylation in Escherichia coli
- Paclitaxel/carboplatin with or without belinostat as empiric first‐line treatment for patients with carcinoma of unknown primary site: A randomized, phase 2 trial
- Targeting Chromatin-Mediated Transcriptional Control of Gene Expression in Non-Small Cell Lung Cancer Therapy: Preclinical Rationale and Clinical Results
- Histone deacetylase inhibitors: a novel class of anti-cancer agents on its way to the market.
- HDAC2 deregulation in tumorigenesis is causally connected to repression of immune modulation and defense escape
- Down‐Regulation of Thioredoxin1 Is Involved in Death of Calu‐6 Lung Cancer Cells Treated With Suberoyl Bishydroxamic Acid
- Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy
- HDAC inhibitor confers radiosensitivity to prostate stem-like cells
- SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells.
- Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin
- HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade
- Gene regulation by melatonin linked to epigenetic phenomena.
- Histone Deacetylase Inhibitors in Malignant Pleural Mesothelioma
- Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors.
- EPIGENETIC TARGETING IN BREAST CANCER: THERAPEUTIC IMPACT AND FUTURE DIRECTION
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