B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy.
Explore this paper's citation graph
Summary
Interaction of B 7-1 and B7-2 with shared counterreceptors CD28 and CTLA-4 results in very different outcomes in clinical disease by influencing commitment of precursors to a Th1 or Th2 lineage.
- Type
- article
- Published
- 1995-03-10
- Cited by
- 1,869
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2040838085
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17138876
Keywords
Biology, Immunology, Experimental autoimmune encephalomyelitis, Antibody, CD28
References
- Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes.
- Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.
- In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2.
- Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4.
- Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression
- Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.
- Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function
- Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain
- Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.
- Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.
- Treatment of murine lupus with CTLA4Ig.
- Divergent T-cell cytokine patterns in inflammatory arthritis.
- Lymphocyte responses and cytokines.
- Acquisition of lymphokine-producing phenotype by CD4+ T cells.
- Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule.
- CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
- CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
- CTLA-4 can function as a negative regulator of T cell activation.
- Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.
- Acute Experimental Allergic Encephalomyelitis in SJL/J Mice Induced by a Synthetic Peptide of Myelin Proteolipid Protein a
Cited by
- Induction of ocular inflammation by T-helper lymphocytes type 2.
- B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.
- T-Cell Subsets: Who does the polarizing?
- CTLA-4-Fc treatment of ongoing EAE improves recovery, but has no effect upon relapse rate. Implications for the mechanisms involved in disease perpetuation.
- CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases.
- Development of th 1- or th 2-dominated immune responses: what about the polarizing signals?
- Limited role of CD28-mediated signals in T helper subset differentiation
- Granulocyte-macrophage colony-stimulating factor and the immune system
- Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats.
- CD86 (B7–2) antigen on B cells from atopic patients shows selective, antigen‐specific upregulation
- Infectious complications occurring in liver transplant recipients receiving mycophenolate mofetil.
- Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells.
- Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes
- Costimulatory molecules and cytotoxic T cells in chronic hepatitis C: defence mechanisms devoted to host integrity or harmful events favouring liver injury progression? A review.
- Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo.
- T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal.
- Altered expression of costimulatory molecules in myasthenia gravis
- Melphalan and Other Anticancer Modalities Up-Regulate B7-1 Gene Expression in Tumor Cells1
- The Neuroimmunology of Multiple Sclerosis: Possible Roles of T and B Lymphocytes in Immunopathogenesis
- Development of Spontaneous Autoimmune Peripheral Polyneuropathy in B7-2–Deficient Nod Mice
Related papers
- A novel receptor involved in T-cell activation
- Coordinate Regulation of T Cell Activation by CD2 and CD281
- Synergy between CD28 and CD9 costimulation for naive T-cell activation.
- CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
- Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation.
- In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation
- Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
- CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
- Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability.