Low-dose memantine-induced working memory improvement in the allothetic place avoidance alternation task (APAAT) in young adult male rats
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Summary
It is suggested that in naïve rats mild NMDAR blockade by low-dose memantine improves working memory related to a highly challenging task.
- Type
- article
- Published
- 2013-12-18
- Cited by
- 21
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011319104
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2904915
Keywords
Memantine, Alternation (linguistics), Task (project management), Psychology, Spontaneous alternation
References
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- Working Memory Training Promotes General Cognitive Abilities in Genetically Heterogeneous Mice
- NMDA Receptors Subserve Persistent Neuronal Firing During Working Memory In Dorsolateral Prefrontal Cortex
- Cumulative benefits of frontal transcranial direct current stimulation on visuospatial working memory training and skill learning in rats.
- Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience.
- The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
- A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats
- Visuospatial working memory is impaired in an animal model of schizophrenia induced by acute MK-801: an effect of pretraining.
- Low Doses of Memantine Disrupt Memory in Adult Rats
- Spatial learning deficit after NMDA receptor blockade and state-dependency.
- Storage of Spatial Information by the Maintenance Mechanism of LTP
- NMDA receptor antagonists can enhance or impair learning performance in animals
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- The associative-memory basis of cognitive skill learning: adult age differences.
Cited by
- Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy
- MRZ-99030 - A novel modulator of Aβ aggregation: II - Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice.
- Cognitive Deficits in Schizophrenia and Other Neuropsychiatric Disorders: Convergence of Preclinical and Clinical Evidence
- Improvement of a Woman’s Alcohol-Related Dementia via Off-label Memantine Treatment
- MK-801 and memantine act differently on short-term memory tested with different time-intervals in the Morris water maze test.
- Higher doses of (+)MK-801 (dizocilpine) induced mortality and procedural but not cognitive deficits in delayed testing in the active place avoidance with reversal on the Carousel.
- Bio-behavioural effects of novel glutamate active compounds in a rodent model of depression
- Memantine improves outcomes after repetitive traumatic brain injury
- Analysis of behaviour in the Active Allothetic Place Avoidance task based on cluster analysis of the rat movement motifs
- A therapeutic dose of memantine improves the performance of rats in an active place avoidance task under the continuous dissociation of distal room and proximal arena cues.
- Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia
- Spatial working memory in rats: crucial role of the hippocampus in the allothetic place avoidance alternation task demanding stimuli segregation.
- Strategies discovery in the active allothetic place avoidance task
- Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity
- Memantine: Updating a rare success story in pro-cognitive therapeutics.
- Memantine and the Kynurenine Pathway in the Brain: Selective Targeting of Kynurenic Acid in the Rat Cerebral Cortex
- Baseline-dependent enhancement of working memory by memantine in male rats: Involvement of NMDA receptor subunits and CaMKII signaling.
- Ketamine Reverses Chronic Stress‐Induced Behavioral Changes via the Expression of Ca2+‐Permeable AMPA Receptors in Mice
- Memantine: updates from the past decade and implications for future novel therapeutic applications
- Effects of High-Dose Memantine on Behavior in Mice with Different Brain Weights
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- Discussion
- Ontogenetic aspects of central cholinergic involvement in spontaneous alternation behavior.