A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats
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Summary
The data suggest that treatment with MK801 to generate an acute psychotic episode in rats, gives rise to grave disturbances in synaptic plasticity and is associated with lasting impairments with the ability to form spatial memory.
- Type
- article
- Published
- 2008-02-01
- Cited by
- 154
- References
- 70
- OpenAlex
- https://openalex.org/W1995336243
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42273100
Keywords
Prepulse inhibition, Schizophrenia (object-oriented programming), Psychosis, Long-term potentiation, Neuroscience
References
- NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory
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- Physiological and pharmacological profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation.
- A single pretreatment with MK-801 or cocaine enhances their locomotor stimulant effects in rats.
- Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats.
- A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities.
- Topiramate antagonizes MK-801 in an animal model of schizophrenia.
- Chronic Pubertal, but not Adult Chronic Cannabinoid Treatment Impairs Sensorimotor Gating, Recognition Memory, and the Performance in a Progressive Ratio Task in Adult Rats
- Memory formation by neuronal synchronization.
- Reduced GABA uptake sites in the temporal lobe in schizophrenia.
- The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine
- Schizophrenics show spatial working memory deficits.
- Cell biology of the hippocampal formation in schizophrenia.
- Clozapine but not haloperidol antagonizes an MK-801 discriminative stimulus cue.
- Dopamine receptor gene expression in hippocampus is differentially regulated by the NMDA receptor antagonist MK-801.
Cited by
- Prenatal Choline Supplementation and MK-801 Toxicity: Protecting Memory and Preventing Neurodegeneration
- Signaling pathways relevant to cognition-enhancing drug targets.
- 13C NMRS of animal models of schizophrenia
- Characterization of the discriminative stimulus effects of nitrous oxide
- Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV‐1 Tat
- Mechanisms of HIV-associated neurotoxicity: Tat-induced synapse loss and recovery
- Making a mouse model for schizophrenia:Using the mouse to model the schizophreniasusceptibility gene ZNF804A
- Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis
- Synaptische Plastizität im Subikulum und ihre Veränderung im MK-801 Tiermodell der Psychose
- Anti-NMDA-Rezeptor-Enzephalitis
- The Effect of Subchronic Dosing of Ciproxifan and Clobenpropit on Dopamine and Histamine Levels in Rats
- The N-methyl-D-aspartate receptor antagonist CPP alters synapse and spine structure and impairs long-term potentiation and long-term depression induced morphological plasticity in dentate gyrus of the awake rat.
- PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis
- Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5
- Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning
- Object location memory in mice: pharmacological validation and further evidence of hippocampal CA1 participation.
- Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter‐1 (GlyT1)
- State-dependent increase of cortical gamma activity during REM sleep after selective blockade of NR2B subunit containing NMDA receptors.
- Differential role of NR2A and NR2B subunits in NMDA receptor antagonist-induced aberrant cortical gamma oscillations
- New promises for manipulation of kynurenine pathway in cancer and neurological diseases
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