Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments
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Summary
The comparison of multiple genomes demonstrates that the M. tuberculosis genome is currently undergoing an active process of gene decay, analogous to the adaptation process of obligate bacterial symbionts.
- Type
- article
- Published
- 2008-11-07
- Cited by
- 38
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011185704
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8002301
Keywords
Genome, Biology, Genetics, Comparative genomics, Genomics
References
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- An outbreak involving extensive transmission of a virulent strain of Mycobacterium tuberculosis.
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- The microbial pan-genome.
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- Microbial genome evolution: sources of variability.
- A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes
- IS6110 functions as a mobile, monocyte‐activated promoter in Mycobacterium tuberculosis
- Genes required for mycobacterial growth defined by high density mutagenesis
- The control of copy number of IS6110 in Mycobacterium tuberculosis.
- The W-Beijing Lineage of Mycobacterium tuberculosis Overproduces Triglycerides and Has the DosR Dormancy Regulon Constitutively Upregulated
- Widespread dissemination of a drug-susceptible strain of Mycobacterium tuberculosis.
Cited by
- SNP/RD Typing of Mycobacterium tuberculosis Beijing Strains Reveals Local and Worldwide Disseminated Clonal Complexes
- Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement
- Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
- Proteins with Complex Architecture as Potential Targets for Drug Design: A Case Study of Mycobacterium tuberculosis
- Truncated Rv2820c enhances mycobacterial virulence ex vivo and in vivo.
- IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes
- DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection.
- A novel site of insertion of IS6110 in the moaB3 gene of a clinical isolate of Mycobacterium tuberculosis
- Transcriptional Regulation of Mycobacterium tuberculosis PE/PPE Genes: A Molecular Switch to Virulence
- The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-Specific Locus and Genome Erosion Common to the M. tuberculosis Complex
- Genomic Signatures of the Haarlem Lineage of Mycobacterium tuberculosis: Implications of Strain Genetic Variation in Drug and Vaccine Development
- Integrative analysis of transcriptome and genome indicates two potential genomic islands are associated with pathogenesis of Mycobacterium tuberculosis.
- Comparative metabolic capabilities for Micrococcus luteus NCTC 2665, the "Fleming" strain, and actinobacteria.
- Influence of M. tuberculosis Lineage Variability within a Clinical Trial for Pulmonary Tuberculosis
- atpE gene as a new useful specific molecular target to quantify Mycobacterium in environmental samples
- Biochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated Variants
- Secretome profile analysis of hypervirulent Mycobacterium tuberculosis CPT31 reveals increased production of EsxB and proteins involved in adaptation to intracellular lifestyle.
- Clonación del gen rv1411 de Mycobacterium tuberculosis H37Rv en Escherichia coli y su integración en el genoma de Pichia methanolica
- Review on Molecular Mechanism of First Line Antibiotic Resistance in Mycobacterium tuberculosis
- Genomics and Genome Evolution of Mycobacterium tuberculosis*: Genomics and Genome Evolution of Mycobacterium tuberculosis*
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