Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
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Summary
In conclusion, these data are compatible with the hypothesis that apoptotic ΔΨ m disruption is mediated by the formation of PT pores and that PT‐mediated ΔΩ mruption is a critical event of the apoptotic cascade.
- Type
- article
- Published
- 1996-04-08
- Cited by
- 468
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2009543520
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33885527
Keywords
Mitochondrial permeability transition pore, Apoptosis, Cell biology, Membrane potential, Mitochondrion
References
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- Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone.
- The biochemistry of programmed cell death
- Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.
- Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase.
- Novel mechanisms in chemically induced hepatotoxicity 1
- The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore.
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- Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane
- Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: the role of mitochondria.
- Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo
- A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
- Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.
- Importance of loops of mitochondrial ADP/ATP carrier for its transport activity deduced from reactivities of its cysteine residues with the sulfhydryl reagent eosin-5-maleimide.
- Flow cytometric analysis of altered mononuclear cell transmembrane potential induced by cyclosporin.
- Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B
Cited by
- Two distinct modes of oncoprotein expression during apoptosis resistance in vincristine and daunorubicin multidrug-resistant HL60 cells.
- alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells.
- Genistein Induces Apoptosis in T Lymphoma Cells via Mitochondrial Damage
- Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.
- Molecular and cellular mechanisms of T lymphocyte apoptosis.
- The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro
- A mini review of fluoride-induced apoptotic pathways
- Investigations into the molecular mechanism of apoptosis
- Parkinson's Disease: Mechanisms of Neuronal Death
- Reactive oxygen species, mitochondria, apoptosis and aging
- Etude des effets mitochondriaux du monoxyde d'azote : Régulation de l'oxydation phosphorylante et de la transition de perméabilité
- The Broad Spectrum HDAC Inhibitor PCI-24781 Induces Caspase- and ROS-Dependent Apoptosis and is Synergistic with Bortezomib in Lymphoma
- Mechanism of cytotoxic action of perfluorinated acids II. Disruption of mitochondrial bioenergetics.
- Role of the Mitochondrial Permeability Transition Pore in Apoptosis
- Palmitate induces apoptosis via a direct effect on mitochondria
- Physiology of apoptosis.
- Caspase cascades in chemically-induced apoptosis.
- Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?
- Régulation du Pore de Transition de Perméabilité mitochondrial et toxicité induite par les analogues de l'ubiquinone dans les hépatocytes cancéreux.
- Mise en évidence d'un marqueur de bon pronostic dans le glioblastome multiforme, l'enzyme mPGES-1 : identification de son produit PGE2 comme un nouvel activateur direct de la protéine pro-apoptotique Bax
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