Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
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Summary
Understanding the molecular events that regulate apoptosis in response to anticancer chemotherapy, and how cancer cells evade apoptotic death, provides novel opportunities for a more rational approach to develop molecular-targeted therapies for combating cancer.
- Type
- review
- Published
- 2006-08-07
- Cited by
- 2,356
- References
- 174
- OpenAlex
- https://openalex.org/W2009183786
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28945764
Keywords
Apoptosis, Biology, Programmed cell death, Cancer research, Suicide gene
References
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- PUMA induces the rapid apoptosis of colorectal cancer cells.
- Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
- Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ *
- Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma
- FoxO3a Transcriptional Regulation of Bim Controls Apoptosis in Paclitaxel-treated Breast Cancer Cell Lines*
- Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4
- The role of apoptosis in cancer development and treatment response
- Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
- Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
- A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
- CD95's deadly mission in the immune system
- Defying death after DNA damage
- Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
- The biochemistry of apoptosis
- Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.
- The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems.
- STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs.
- A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
- Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia.
Cited by
- Extracellular Ubiquitin: Role in Myocyte Apoptosis and Myocardial Remodeling
- ANTICANCER ACTIVITY OF NATURAL HEALTH PRODUCTS (DANDELION ROOT & LONG PEPPER EXTRACTS); EXTENSIVE STUDY OF EFFICACY AND MECHANISM OF ACTION
- Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
- PDCD5 promotes cisplatin-induced apoptosis of glioma cells via activating mitochondrial apoptotic pathway
- X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells
- Etoposide sensitizes neuroblastoma cells expressing caspase 8 to TRAIL
- A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells.
- Membrane localized iridium(III) complex induces endoplasmic reticulum stress and mitochondria-mediated apoptosis in human cancer cells.
- Activation of extrinsic apoptotic pathway from bladder biopsy in patients with interstitial cystitis/painful bladder syndrome.
- Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells.
- Tetrastigma hemsleyanum (Sanyeqing) root tuber extracts induces apoptosis in human cervical carcinoma HeLa cells.
- Targeting IAP proteins in combination with radiotherapy
- Novel walnut peptide–selenium hybrids with enhanced anticancer synergism: facile synthesis and mechanistic investigation of anticancer activity
- Knockdown of miR-182 promotes apoptosis via regulating RIP1 deubiquitination in TNF-α-treated triple-negative breast cancer cells
- Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III
- Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line.
- Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis
- Exploring the influence of culture conditions on kefir's anticancer properties.
- Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericum ascyron L.
- Induction of Apoptosis by Citrus unshiu Peel in Human Breast Cancer MCF-7 Cells: Involvement of ROS-Dependent Activation of AMPK.
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