Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
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Summary
It is reported here that micromolar concentrations of Ins1,4,5P3 release Ca2+ from a nonmitochondrial intracellular Ca2- store in pancreatic acinar cells, and the results strongly suggest that this is the same Ca1+ store that is released by acetylcholine.
- Type
- article
- Published
- 1983-11-03
- Cited by
- 2,266
- References
- 19
- OpenAlex
- https://openalex.org/W2008245136
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4359904
Keywords
Inositol, Phosphatidylinositol, Intracellular, Inositol trisphosphate, Calcium
References
- The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain.
- Complete characterization of the myo-inositol polyphosphates from beef brain phosphoinositide.
- Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas.
- Phosphatidylinositol phosphodiesterase in higher plants.
- Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
- Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices.
- Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes.
- Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.
- Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
- A simple system for the measurement of ion activities with solvent polymeric membrane electrodes.
- Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism
- Compartmentation of calcium in digitonin-disrupted guinea pig pancreatic acinar cells.
- Inositol phospholipids and cell surface receptor function.
- Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.
- Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells.
- The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
- Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function.
- Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate.
- Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase.
Cited by
- GTP enhances inositol trisphosphate‐stimulated Ca2+ release from rat liver microsomes
- Increased turnover of platelet phosphatidylinositol in schizophrenia.
- Mechanisms of activated Ca2+ entry in the rat pancreatoma cell line, AR4-2J.
- Dual effect of magnesium on compound 48/80-induced histamine secretion from rat peritoneal mast cells.
- Effects of antibodies to myosin light chain kinase on contractility and myosin phosphorylation in chemically permeabilized smooth muscle.
- Second messengers derived from inositol lipids
- Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone.
- Second Messengers Are Involved in Facilitatory but Not Inhibitory Receptor Actions at Sympathetic Nerve Endings
- Activation of the endoplasmic reticulum Ca2+ pump of pancreatic acini by Ca2+ mobilizing hormones.
- Neurotransmitter‐Induced Inositol Phosphate Formation in Neurons in Primary Culture
- Agonist-induced hydrolysis of phosphoinositides and formation of 1,2-diacylglycerol in adult human keratinocytes.
- Identification of a Ca2+-ATPase in cerebellar Purkinje cells.
- Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor
- Inositol 1-phosphate formation in long-term potentiation and kindling.
- Effects of Phorbol Esters and Forskolin on Basal and Histamine‐induced Accumulation of Inositol Phosphates in Cultured Bovine Adrenal Chromaffin Cells
- Putative role of inositol phospholipid metabolism in neurons.
- Molecular mechanism of gonadotropin releasing hormone action. II. The effector system.
- Structural Basis for Arachidonic Acid Second Messenger Signal in Gamma‐Interferon Induction a
- Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C
- The influence of extracellular calcium on the distribution of protein kinase C in non-neoplastic and neoplastic rat liver cells.
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