Stimulation of luteinizing hormone release by sodium fluoride is independent of protein kinase-C activity and unaffected by desensitization to gonadotropin-releasing hormone.
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Summary
The results support a role for a G-protein in regulation of LH release by the releasing hormone, and suggest that PKC does not mediate sodium fluoride effects.
- Type
- article
- Published
- 1990-05-01
- Cited by
- 15
- References
- 52
- OpenAlex
- https://openalex.org/W2158431
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20598696
Keywords
Mars Exploration Program, Astrobiology, Physics
References
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- Protein kinase C-mediated gonadotropin-releasing hormone receptor sequestration is associated with uncoupling of phosphoinositide hydrolysis.
- Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs.
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- Further evidence for a phospholipase C-coupled G protein in hamster fibroblasts. Induction of inositol phosphate formation by fluoroaluminate and vanadate and inhibition by pertussis toxin.
- Double-antibody method and the protein-A-bearing Staphylococcus aureus cells method compared for separating bound and free antigen in radioimmunoassay.
- THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
- The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
- Studies and perspectives of protein kinase C.
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Cited by
- Receptors and signal transduction in the pars intermedia of Xenopus laevis
- Molecular and cellular bases of gonadotropin-releasing hormone action in the pituitary and central nervous system.
- Assessment of the role of G proteins and inositol phosphate production in the action of gonadotropin-releasing hormone.
- Dual effects of fluoroaluminate on activation of calcium influx and inhibition of agonist-induced calcium mobilization in rat glomerulosa cells.
- Activin modulates the intracellular signaling system activated by gonadotropin-releasing hormone: dual effect on calcium messenger system and protein kinase-C pathway.
- Actions of GnRH Agonists on Gonadotrope Physiology
- Hormonal desensitization: Comparison of the gonadotropin-hormone-releasing-hormone and beta-Adrenergic receptor- effector systems.
- The use of flufenamate and forskolin to evaluate the role of cAMP in gonadotropin-releasing hormone-stimulated luteinizing hormone secretion from pituitaries of ovariectomized rats.
- Sodium fluoride provokes gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and gonadotrope sensitization to A23187: evidence for multiple G proteins in GnRH action.
- Selection of models for the study of GnRH stimulated gonadotropin release prejudices the assignment of roles for mediators and modulators of hormone action.
- Modulation of the expression of murine lupus by gonadotropin-releasing hormone analogs.
- Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC.
- Gonadotropin-releasing hormone and its analogues.
- GnRH and Its Mechanism of Action
- Gonadotropin Releasing Hormone and Its Actions
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