Inositol 1,2-cyclic 4,5-trisphosphate is an order of magnitude less potent than inositol 1,4,5-trisphosphate in mobilizing intracellular stores of calcium in mouse pancreatic acinar cells.
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Summary
Results suggest that inositol 1,2-cyclic 4,5-trisphosphate is unlikely to play any significant role in Ca2+ mobilization, at least in mouse pancreatic acinar cells.
- Type
- article
- Published
- 1989-03-15
- Cited by
- 11
- References
- 16
- OpenAlex
- https://openalex.org/W2064525306
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19252767
Keywords
Inositol, Inositol trisphosphate, Inositol trisphosphate receptor, Inositol phosphate, Intracellular
References
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- Kinetics of inositol 1,4,5-trisphosphate and inositol cyclic 1:2,4,5-trisphosphate metabolism in intact rat parotid acinar cells. Relationship to calcium signalling.
- Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells.
- Activation of sea urchin eggs by inositol phosphates is independent of external calcium.
- Molecular mechanisms of transmembrane signalling
- Characterization of inositol 1,4,5-trisphosphate receptors and calcium mobilization in a hepatic plasma membrane fraction.
- Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.
- Potentiation by glucose metabolites of inositol trisphosphate-induced calcium mobilization in permeabilized rat pancreatic islets.
- The formation of inositol 1,2-cyclic 4,5-trisphosphate and inositol 1,2-cyclic 4-bisphosphate on stimulation of mouse pancreatic minilobules with carbamylcholine.
- Inositol 1,2-cyclic 4,5-trisphosphate concentration relative to inositol 1,4,5-trisphosphate in pancreatic minilobules on stimulation with carbamylcholine in the absence of lithium. Possible role as a second messenger in long- but not short-term responses.
- The gyroscope test of relativity
- Inositol trisphosphate, a novel second messenger in cellular signal transduction
- Receptors and phosphoinositide-generated second messengers.
- THE EFFECTS OF SECRETAGOGUES ON THE INCORPORATION OF [2-3H]MYOINOSITOL INTO LIPID IN CYTOLOGICAL FRACTIONS IN THE PANCREAS OF THE GUINEA PIG IN VIVO
- Inositol trisphosphate and diacylglycerol: two interacting second messengers.
- Inositol 1,2-cyclic 4,5-trisphosphate is formed in the rat parotid gland on muscarinic stimulation.
Cited by
- History of phosphoinositide research.
- Regulation of the metabolism of 1,2-diacylglycerols and inositol phosphates that respond to receptor activation.
- The inositol phosphate-calcium signaling system in nonexcitable cells.
- Pharmacologic Characterization of the Inositol Trisphosphate Receptor in Rat Pancreas
- The partial chemical synthesis of inositol 1,2-cyclic 4,5-trisphosphate.
- Cyclic and noncyclic inositol phosphates are formed at different ratios by phospholipase C isozymes.
- Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores.
- Receptors and the Inositol Phosphate-Calcium Signaling System
- General Aspects of Calcium Signaling
- CHAPTER 13 – REGULATION OF THE METABOLISM OF 1,2-DIACYLGLYCEROLS AND INOSITOL PHOSPHATES THAT RESPOND TO RECEPTOR ACTIVATION
- Inositol Phosphate Metabolism
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