International trial of the Edmonton protocol for islet transplantation.
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Summary
Islet transplantation with the use of the Edmonton protocol can successfully restore long-term endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus and unstable control, but insulin independence is usually not sustainable.
- Type
- article
- Published
- 2006-09-28
- Cited by
- 1,773
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2006919788
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21764259
Keywords
Medicine, Transplantation, Glycemic, Islet, Hypoglycemia
References
- Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
- Current Human Islet Isolation Protocol
- Transplantation of Cultured Islets from Two‐Layer Preserved Pancreases in Type 1 Diabetes with Anti‐CD3 Antibody
- Human islet transplantation network for the treatment of Type I diabetes: first data from the Swiss-French GRAGIL consortium (1999–2000)
- Development of a Chimeric Anti-CD40 Monoclonal Antibody That Synergizes with LEA29Y to Prolong Islet Allograft Survival1
- The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.
- Kinetics of diabetes-associated autoantibodies after sequential intraportal islet allograft associated with kidney transplantation in type 1 diabetes.
- PANCREATIC ISLET TRANSPLANTATION: THE RADIOGRAPHIC APPROACH
- Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.
- Development of a human pancreatic islet-transplant program through a collaborative relationship with a remote islet-isolation center
- Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?
- Islet Transplantation in Type 1 Diabetes Mellitus Using Cultured Islets and Steroid‐Free Immunosuppression: Miami Experience
- Comparison of whole organ pancreas and isolated islet transplantation for type 1 diabetes.
- Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment
- Strategic opportunities in clinical islet transplantation.
- Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects.
- The Portal Immunosuppressive Storm: Relevance to Islet Transplantation?
- Effect of the immunosuppressive regime of Edmonton protocol on the long-term in vitro insulin secretion from islets of two different species and age categories.
- Diabetes Therapeutics News
- Natural history of intrahepatic canine islet cell autografts.
Cited by
- Challenges and prospects for stem cell-based therapy in diabetes mellitus.
- Islet cell transplantation for Type 1 diabetes
- Glucose regulation of β‐cell stress in type 2 diabetes
- Pancreatic islet transplantation.
- Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy
- Application of an Endothelialized Modular Construct for Islet Transplantation in Syngeneic and Allogeneic Immunosuppressed Rat Models
- Endothelin-1 markedly decreases the blood perfusion of transplanted pancreatic islets in rats.
- Common Pancreatic Disease
- Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation
- Modest effects of Fas-ligand and heme oxygenase-1 double transgenic mouse islets on transplantation outcomes.
- Functional enhancement of beta cells in transplanted pancreatic islets by secretion signal peptide-linked exendin-4 gene transduction.
- Magnetic Resonance Imaging of Mouse Islet Grafts Labeled with Novel Chitosan-Coated Superparamagnetic Iron Oxide Nanoparticles
- Differentiation and lineage commitment of murine embryonic stem cells into insulin producing cells.
- The Use of 1.5-Anhydroglucitol for Monitoring Glycemic Control in Islet Transplant Recipients
- Pancreas transplantation: solid organ and islet.
- Transplantation of Heterospheroids of Islet Cells and Mesenchymal Stem Cells for Effective Angiogenesis and Antiapoptosis
- Role of sex steroids in β-cell function, growth and survival
- Islet cell transplant: Update on current clinical trials
- Local delivery of fingolimod from three‐dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model
- 3D Printed Vascularized Device for Subcutaneous Transplantation of Human Islets.
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