Differentiation and lineage commitment of murine embryonic stem cells into insulin producing cells.
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Summary
This work investigated whether ectopic expression of pancreatic and duodenal homeobox 1 (Pdx1), an essential pancreatic transcription factor, in mouse ES cells leads to enhanced differentiation into IPCs.
- Type
- article
- Published
- 2013-01-01
- Cited by
- 12
- References
- 51
- OpenAlex
- https://openalex.org/W23756944
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30806841
Keywords
Amazon rainforest, Geography, Humanities, Art, Biology
References
- Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
- Gene transfer to the brain using feline immunodeficiency virus-based lentivirus vectors.
- Purification of proteins from baculovirus-infected insect cells.
- PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
- The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.
- Biphasic Induction of Pdx1 in Mouse and Human Embryonic Stem Cells Can Mimic Development of Pancreatic β‐Cells
- Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic β-like cells
- The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
- Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss
- Finding new treatments for diabetes--how many, how fast... how good?
- Insulin-promoter-factor 1 is required for pancreas development in mice
- International trial of the Edmonton protocol for islet transplantation.
- The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
- Insulin Producing Cells Derived from Embryonic Stem Cells: Are We There Yet?
- Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion*
- Rfx6 Directs Islet Formation and Insulin Production in Mice and Humans
- Inducing Embryonic Stem Cells to Differentiate into Pancreatic β Cells by a Novel Three‐Step Approach with Activin A and All‐Trans Retinoic Acid
- Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
- Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation*
- PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.
Cited by
- Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells.
- Myocardin and pdx-1 synergistically induce hMSCs to differentiate into insulin secreting cells.
- Stem Cells Therapy in Diabetes Mellitus
- Towards in Vitro Generation of Functional Insulin Producing Cell Lineage for Diabetes Therapy
- Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities
- 3D differentiation enhances the efficiency of differentiation of human induced pluripotent stem cells to insulin producing cells
- Differentiation of Mesenchymal Stem Cells to Insulin Producing Cells Using the Extracts of Allium ursinum and Silybum marianum
- The Synergy of Two Factors on Insulin Expression
- Differentiation of mouse embryonic stem cells into insulin-producing cells: optimization to enhance the overall differentiation efficiency
- Are Tanycytes the missing link between Type 2 Diabetes and Alzheimer’s Disease?
- DIABETES MELLITUS TREATMENT: A RAPID REVIEW ON INNOVATIVE THERAPIES
- Decellularized Wharton's jelly scaffold enhances differentiation of mesenchymal stem cells to insulin-secreting cells.
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