DLK1 is a novel inflammatory inhibitor which interferes with NOTCH1 signaling in TLR‐activated murine macrophages
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Summary
Overall, these results reveal a novel role for DLK1 as a regulator of NOTCH‐mediated, pro‐inflammatory macrophage activation, which could help to ensure a baseline level preventing constant tissue inflammation.
- Type
- article
- Published
- 2015-09-01
- Cited by
- 22
- References
- 41
- Access
- Open access
- OpenAlex
- https://openalex.org/W1485320321
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22974163
Keywords
Cell biology, TLR4, RELB, Inflammation, Signal transduction
References
- Inhibition of Notch Signaling Protects Mouse Lung Against Zymosan-Induced Injury
- The role of the epidermal growth factor-like protein dlk in cell differentiation.
- Role of the Non‐Canonical Notch Ligand Delta‐Like Protein 1 in Hormone‐Producing Cells of the Adult Male Mouse Pituitary
- Notch-1 Up-Regulation and Signaling following Macrophage Activation Modulates Gene Expression Patterns Known to Affect Antigen-Presenting Capacity and Cytotoxic Activity1
- Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1
- Notch1 upregulates LPS‐induced macrophage activation by increasing NF‐κB activity
- dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats.
- Involvement of Notch Signaling Pathway in Regulating IL-12 Expression via c-Rel in Activated Macrophages
- Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism.
- Delta-like 1/Fetal Antigen-1 (Dlk1/FA1) Is a Novel Regulator of Chondrogenic Cell Differentiation via Inhibition of the Akt Kinase-dependent Pathway*
- Notch signaling is activated by TLR stimulation and regulates macrophage functions
- The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
- Direct regulation of interleukin-6 expression by Notch signaling in macrophages
- Toll-like receptor signalling
- Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways
- Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
- Negative regulation of Toll-like receptor-mediated immune responses
- Dlk1 Influences Differentiation and Function of β Lymphocytes
- Postnatal loss of Dlk1 imprinting in stem cells and niche-astrocytes regulates neurogenesis
- Monitoring Notch1 activity in development: Evidence for a feedback regulatory loop
Cited by
- The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling
- Transgenerational inheritance of increased breast cancer risk in mouse offspring of dams exposed to high fat N-6 polyunsaturated fatty acid diet during pregnancy
- Inhibitory Effect of Low‐Intensity Pulsed Ultrasound on the Expression of Lipopolysaccharide‐Induced Inflammatory Factors in U937 Cells
- Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice
- Comparison of the immune response during acute and chronic Staphylococcus aureus infection
- Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling
- DLK proteins modulate NOTCH signaling to influence a brown or white 3T3-L1 adipocyte fate
- Differential urinary proteomics analysis of myocardial infarction using iTRAQ quantification
- NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
- NOTCH3 signaling is essential for NF-κB activation in TLR-activated macrophages
- Imprinted Genes and Multiple Sclerosis: What Do We Know?
- Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced Delta-like-1 expression
- Essential Role of STAT3 Signaling in Hair Follicle Homeostasis
- The Recombinant Eg.P29-Mediated miR-126a-5p Promotes the Differentiation of Mouse Naive CD4+ T Cells via DLK1-Mediated Notch1 Signal Pathway
- The cellular landscape of the endochondral bone during the transition to extrauterine life
- TRIM67 Promotes Non-Small Cell Lung Cancer Development by Positively Regulating the Notch Pathway through DLK1 Ubiquitination
- DLK1 regulates periodontal inflammation by inhibiting NF-κB p65 and JNK signaling pathways
- Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid model
- DLK1-expressing neural progenitor cells promote tissue repair and functional recovery after cervical spinal cord injury
- IRF7 drives macrophages to kill bacteria and improves septic outcomes via autophagy
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