Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma
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Summary
It is indicated that HES1 is uncoupled from Notch in ESFT, that EWS–FLI1‐mediated inhibition of Notch contributes to ESFT aggressive cell growth, and support a role for NotchIn ESFT tumour suppression, at least partly through the Notch effector HEY1.
- Type
- article
- Published
- 2011-11-01
- Cited by
- 34
- References
- 60
- OpenAlex
- https://openalex.org/W2073929498
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6083002
Keywords
HES1, Notch signaling pathway, Biology, Cancer research, Notch proteins
References
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- Large-scale analysis of the human and mouse transcriptomes
Cited by
- Correlation of Notch1/Hes1 Genes Expression Levels in Egyptian Paediatric Patients with Newly Diagnosed and Persistent Primary Immune(Idiopathic) Thrombocytopenic Purpura
- Biomarkers in the Ewing sarcoma family of tumors
- Differential protein expression and oncogenic gene network link tyrosine kinase ephrin B4 receptor to aggressive gastric and gastroesophageal junction cancers
- Cancer Bioinformatic Methods to Infer Meaningful Data From Small-Size Cohorts
- New Therapeutic Targets in Soft Tissue Sarcoma
- HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors
- Pautas en el diagnóstico morfológico. inmunohistoquímico y genético de los tumores de células redondas y pequeñas con especial referencia al sarcoma de Ewing/PNET
- Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma.
- Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumors.
- Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma.
- Notch signaling in pediatric soft tissue sarcomas
- The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.
- The First European Interdisciplinary Ewing Sarcoma Research Summit
- Inflammation Modulates RLIP76/RALBP1 Electrophile-Glutathione Conjugate Transporter and Housekeeping Genes in Human Blood-Brain Barrier Endothelial Cells
- Galectin-1 Couples Glycobiology to Inflammation in Osteoarthritis through the Activation of an NF-κB–Regulated Gene Network
- Joint Antiangiogenic Effect of ATN-161 and Anti-VEGF Antibody in a Rat Model of Early Wet Age-Related Macular Degeneration.
- CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-kB signaling
- HES1 overexpression promotes cell proliferation and invasion in breast cancer and predicts poor survival
- Homotypic chondro-osseous differentiation, metastasis and osteotropism in Ewing Tumors
- Upregulation of HES1 Promotes Cell Proliferation and Invasion in Breast Cancer as a Prognosis Marker and Therapy Target via the AKT Pathway and EMT Process
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