Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin
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Summary
It is demonstrated that Fn adheres to, invades and induces oncogenic and inflammatory responses to stimulate growth of CRC cells through its unique FadA adhesin.
- Type
- article
- Published
- 2013-08-14
- Cited by
- 2,297
- References
- 51
- Access
- Open access
- OpenAlex
- https://openalex.org/W2006292369
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28733488
Keywords
Biology, Fusobacterium nucleatum, Bacterial adhesin, Cadherin, Colorectal cancer
References
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- Microbiome and Malignancy
- Comparative Microbial Analysis of Paired Amniotic Fluid and Cord Blood from Pregnancies Complicated by Preterm Birth and Early-Onset Neonatal Sepsis
Cited by
- Looking in the Porphyromonas gingivalis’ Cabinet of Curiosities: The Microbium, the Host and Cancer Association
- Oral Bacteria as Drivers for Colorectal Cancer
- Physiological adaptations of key oral bacteria.
- “Messieurs, c'est les microbes qui auront le dernier mot”: Gentlemen, it is the microbes who have the last word (Louis Pasteur)—Fusobacterium nucleatum protect tumors from killing by immune cells
- Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study
- The microbiome and hepatobiliary-pancreatic cancers.
- Host Genetic control of the oral microbiome in Health and Disease
- Indoleamine 2,3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages
- Microbiota, Epithelium, Inflammation, and TGF-β Signaling: An Intricate Interaction in Oncogenesis
- Impact of microbiota in colorectal carcinogenesis: lessons from experimental models
- Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity
- [Research progress on the relationship between periodontal disease and common malignancies].
- Genomic Analysis of Infectious Agents, Mutations and Immune Cells Associated with Cancer
- Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoEnull Mice
- Obesity‐associated gastrointestinal tract cancer: From beginning to end
- Obesity and cancer pathogenesis
- The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?
- Microbiome and Potential Targets for Chemoprevention of Esophageal Adenocarcinoma
- Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment
- Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment
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