GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
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Summary
Inter-tissue communication results in adaptations to impaired glucose transport in muscle and adipocytes that involve increased hepatic glucose uptake and lipid synthesis, while muscle adapts by preferentially utilizing lipid fuels.
- Type
- article
- Published
- 2004-12-01
- Cited by
- 143
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2004889053
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22620329
Keywords
Internal medicine, Endocrinology, GLUT4, Insulin resistance, Glucose uptake
References
- Type 2 diabetes — who is conducting the orchestra?
- Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
- Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
- Sympathetic denervation impairs responses of brown adipose tissue to VMH stimulation.
- Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice.
- Discrete brain areas express the insulin-responsive glucose transporter GLUT4.
- Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats.
- Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase*
- Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man.
- Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin
- Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
- Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene.
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
- Anatomical and developmental patterns of facilitative glucose transporter gene expression in the rat kidney.
- Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
- Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
- A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
- GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes
- Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain.
- Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart.
Cited by
- Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice.
- C5L2 receptor disruption enhances the development of diet-induced insulin resistance in mice.
- ChREBP regulates fructose-induced glucose production independently of insulin signaling.
- [Role of metabolic lipases and lipotoxicity in the development of non-alcoholic steatosis and non-alcoholic steatohepatitis].
- Avaliação da via inibitória do sinal insulínico em ratos tratados cronicamente com fluoreto de sódio
- REFEIÇÕES RICAS EM CARBOIDRATOS OU LIPÍDEOS DIMINUEM A SENSIBILIDADE À INSULINA DUAS HORAS APÓS O INÍCIO DA INGESTÃO
- [ADVANCES IN PHARMACOLOGICAL AND PHYTOCHEMICAL ADIPOGENESIS THERAPY].
- Role of plasminogen activator inhibitor (PAI-1) in the pathogenesis of fructose-induced non-alcoholic fatty liver disease (NAFLD)
- Hormone-Sensitive Lipase - New roles in adipose tissue biology
- Genetic and non-genetic determinants of skeletal muscle GLUT4 mRNA levels and insulin action in twins.
- 리치 저분자 폴리페놀인 Oligonol의 Streptozotocin 투여 당뇨 쥐에서 산화적 스트레스와 관련된 간 손상에 미치는 영향
- Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins
- De novo lipogenesis in metabolic homeostasis: More friend than foe?
- Reconstitution of Insulin Action in Muscle, White Adipose Tissue, and Brain of Insulin Receptor Knock-out Mice Fails to Rescue Diabetes*
- Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
- Clinical and laboratory diagnosis of the metabolic syndrome
- Neuronal Glucose Transporter Isoform 3 Deficient Mice Demonstrate Features of Autism Spectrum Disorders
- The Acute Effects of HIV Protease Inhibitors on Insulin Suppression of Glucose Production in Healthy HIV-negative Men
- Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?
- Protective role of Lycopene against Aroclor 1254-induced changes on GLUT4 in the skeletal muscles of adult male rat
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