Twins for epigenetic studies of human aging and development
Explore this paper's citation graph
Summary
The classical twin design is extended to study the aging–related molecular epigenetic phenotypes and link them with environmental exposures especially early life events to make uses of twins in assessing the environmental impact on epigenetic changes during development and in the aging process.
- Type
- review
- Published
- 2012-06-29
- Cited by
- 54
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1999377691
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33932235
Keywords
Epigenetics, Biology, Twin study, Genomics, Phenotype
References
- Ageing and cancer as diseases of epigenesis
- Epigenetic Inheritance and Evolutionary Adaptation
- Twins. Novel uses to study complex traits and genetic diseases.
- Heritability of Cognitive Functions in Families of Successful Cognitive Aging Probands from the Central Valley of Costa Rica
- Genetic inheritance of gene expression in human cell lines.
- The Application of Next Generation Sequencing in DNA Methylation Analysis
- Epigenetics of Personality Traits: An Illustrative Study of Identical Twins Discordant for Risk-Taking Behavior
- Trends in health expectancy at age 65 for various health indicators, 1987–2005, Denmark
- 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation
- Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
- Epigenetics as a unifying principle in the aetiology of complex traits and diseases
- The epigenetics of social adversity in early life: implications for mental health outcomes.
- Dissecting complex phenotypes using the genomics of twins
- The early life environment and the epigenome.
- Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease
- Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity
- Quantitative genetic analysis of latent growth curve models of cognitive abilities in adulthood.
- Genetic influence on human lifespan and longevity
- ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
- Long noncoding RNAs and human disease.
Cited by
- Inflammation, advancing age and nutrition
- Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics
- Annual research review: The (epi)genetics of neurodevelopmental disorders in the era of whole-genome sequencing--unveiling the dark matter.
- Genetic Influences on Brain Developmental Trajectories on Neuroimaging Studies: From Infancy to Young Adulthood
- Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals
- Polymorphic Variation in the Epigenetic Gene DNMT3B Modulates the Environmental Impact on Cognitive Ability: A Twin Study
- The heritability of leucocyte telomere length dynamics
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
- Probing genetic overlap in the regulation of systolic and diastolic blood pressure in Danish and Chinese twins
- Epigenetic Epidemiology of Complex Diseases Using Twins
- Epigenetic signature of birth weight discordance in adult twins
- Genetic investigation into ethnic disparity in polycystic ovarian syndrome
- Twin methodology in epigenetic studies
- Epigenetics and aging.
- Developmental genes targeted for epigenetic variation between twin-twin transfusion syndrome children
- Genetic Determinants of Healthy Aging Studies of genetic variation associated with human longevity
- Genetic factors and epigenetic mechanisms of longevity: current perspectives.
- Early Neurodevelopment, adult human cognition and depressive psychopathology: analysis of neuroimaging brain correlates and epigenetic mediators
- Auswirkungen ausgewählter Einflussfaktoren auf die genomweite DNA-Methylierung beim Menschen
- The contributions of twin studies to the understanding of brain ageing and neurocognitive disorders
Related papers
- Genetic and environmental impacts on DNA methylation levels in twins.
- DNA methylation in osteoarthritic chondrocytes: a new molecular target.
- Early Nutritional Influences on Human Developmental Epigenetics.
- Oxidative stress and DNA methylation regulation in the metabolic syndrome.
- The Interplay between Dysregulated Metabolism and Epigenetics in Cancer
- Epigenetics of early-life lead exposure and effects on brain development
- Epigenetic mechanisms in Alzheimer's disease: implications for pathogenesis and therapy.
- Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction?
- Mechanisms of epigenetic memory