Ageing and cancer as diseases of epigenesis
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Summary
While first proposed by Boris Vanyushin in 1973, recent studies have confirmed that inappropriate methylation not only causes diseases, and it also may be the critical factor in ageing and cancers.
- Type
- article
- Published
- 2009-09-04
- Cited by
- 33
- References
- 21
- OpenAlex
- https://openalex.org/W19920344
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14293042
Keywords
Medicine
References
- The Consensus Coding Sequences of Human Breast and Colorectal Cancers
- The promise of retinoids to fight against cancer
- Mutator pathways unleashed by epigenetic silencing in human cancer.
- Epigenetics and aging: the targets and the marks.
- Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence.
- Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
- The epigenetic progenitor origin of human cancer
- Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients.
- Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells.
- Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system.
- Cigarette smoke induces demethylation of prometastatic oncogene synuclein-γ in lung cancer cells by downregulation of DNMT3B
- Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.
- Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.
- An elaborate pathway required for Ras-mediated epigenetic silencing
- Differential DNA Hypermethylation of Critical Genes Mediates the Stage-Specific Tobacco Smoke-Induced Neoplastic Progression of Lung Cancer
- Epigenetics and twins: three variations on the theme.
- DNA Methylation in Benign Breast Epithelium in Relation to Age and Breast Cancer Risk
- Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer
- The organizing principle: microenvironmental influences in the normal and malignant breast.
- Developmental Biology
Cited by
- Peroxisome proliferator-activated receptor gamma inhibits cell growth and negatively regulates DNA methyltransferase promoter activity in SK-N-AS neuroblastoma cells
- Epigenetics and the social work imperative.
- Cancer epigenetics.
- Environmental and age effects on methylation changes in human brain and blood cells
- Evolutionary epigenetics of modern human populations
- Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells
- Twins for epigenetic studies of human aging and development
- Present and future of anti-ageing epigenetic diets.
- Nucleic acid therapy for lifespan prolongation: Present and future
- Two opposing roles of O-glycans in tumor metastasis
- A short review on creatine–creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy
- Senescence; an endogenous anticancer mechanism.
- Higher order chromatin organization in cancer
- Characterizing Animal Development with Genetic Regulatory Mechanisms
- Keep‐ING balance: Tumor suppression by epigenetic regulation
- Twin-based DNA methylation analysis takes the center stage of studies of human complex diseases.
- Establishment of Methylation-Specific PCR for the Mouse p53 Gene
- DNA methylation and microRNAs in cancer.
- Glycan changes: cancer metastasis and anti-cancer vaccines
- Semaphorins and their receptors in stem and cancer cells.
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