Molecular cloning of two novel transmembrane ligands for Eph-related kinases (LERKS) that are related to LERK-2.
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Summary
A search of the nucleic acid database of expressed sequence tags (ESTs) revealed several partial cDNA sequences that could encode proteins homologous to the ligands for Eph-related kinases (LERKs) and oligonucleotides designed from the ESTs were used to probe a human brain cDNA library and obtain overlapping clones that encoded two different novel LERKS.
- Type
- article
- Published
- 1996-01-01
- Cited by
- 19
- References
- 26
- OpenAlex
- https://openalex.org/W1999116595
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41528702
Keywords
Erythropoietin-producing hepatocellular (Eph) receptor, Kinase, Cloning (programming), Transmembrane protein, Ephrin
References
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- Cell Signalling: Receptor orphans find a family
- Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation.
Cited by
- Eph receptors and ephrins: regulators of guidance and assembly.
- A family of cytokine-inducible inhibitors of signalling
- Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
- The Eph family receptors and ligands.
- Reciprocal expression of the Eph receptor Cek5 and its ligand(s) in the early retina.
- Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure.
- Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
- Dancing with the dead: Eph receptors and their kinase-null partners.
- Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
- Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas.
- The ephrins and Eph receptors in neural development.
- Ligand for EPH-related Kinase (LERK) 7 Is the Preferred High Affinity Ligand for the HEK Receptor*
- Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
- 'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation.
- Isolation and characterization of "orphan-RTK" ligands using an integrated biosensor approach.
- Regulation of neural connectivity by the Epha4 receptor tyrosine kinase.
- Functional study of ephrins and eph receptors in the immune system
- Summary Ephrin-A 5 induces rounding , blebbing and de-adhesion of EphA 3-expressing 293 T and melanoma cells by CrkII and Rho-mediated signalling
- Overexpression of Lerk-5IEplg5 Messenger RNA: A Novel Marker for Increased Tumorigenicity and Metastatic Potential in Human Malignant Melanomas1
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