A family of cytokine-inducible inhibitors of signalling
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Summary
Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction.
- Type
- article
- Published
- 1997-06-26
- Cited by
- 2,210
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1668039320
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4325620
Keywords
Signal transduction, Biology, Cytokine receptor, JAK-STAT signaling pathway, Cell biology
References
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- Improved tools for biological sequence comparison.
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- Impulse responses in bacterial chemotaxis.
Cited by
- Estrès del reticle endoplasmàtic, inflamació i resistència a la insulina en cèl•lules musculars esquelètiques
- Transcriptional regulation in neutrophils: teaching old cells new tricks.
- Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation.
- Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway
- Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bβ
- Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
- Growth hormone (GH), GH receptor, and signal transduction.
- The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells
- Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway.
- Down‐regulation of Th1 responses in human neonates
- Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.
- Gene expression profiling reveals a highly specialized genetic program of plasma cells.
- Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply.
- Triggering of Toll‐like receptors modulates IFN‐γ signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling
- CIS1, a cytokine-inducible SH2 protein, suppresses BCR/ABL-mediated transformation. Involvement of the ubiquitin proteasome pathway.
- Interferon- : an overview of signals, mechanisms and functions
- Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
- SOCS: role in inflammation, allergy and homeostasis.
- Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression
- Signal transduction pathways: new targets for treating rheumatoid arthritis.
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