Prognostic significance of CDX2 immunoexpression in poorly differentiated clusters of colorectal carcinoma
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Summary
It is suggested that, although loss of CDX2 in the main tumor identifies high-risk patients with high specificity, CDx2-PDC should also be considered inCDX2 main tumor positive cases to predict prognosis.
- Type
- article
- Published
- 2017-08-17
- Cited by
- 7
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2748115762
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20683109
Keywords
CDX2, Medicine, Immunohistochemistry, Colorectal cancer, Internal medicine
References
- Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.
- Reduced CDX2 Expression Predicts Poor Overall Survival in Patients with Colorectal Cancer
- Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients.
- Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells
- Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane.
- The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
- Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
- Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer
- Cdx1 and Cdx2 Function as Tumor Suppressors
- Tumor budding in colorectal carcinoma: time to take notice
- Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status
- New Criteria for Histologic Grading of Colorectal Cancer
- Deregulated homeobox gene expression in cancer: cause or consequence?
- Cdx1 and cdx2 expression during intestinal development.
- Caudal Homeobox Protein Cdx-2 Cooperates with Wnt Pathway to Regulate Claudin-1 Expression in Colon Cancer Cells
- CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia.
- Loss of CDX2/CK20 Expression Is Associated With Poorly Differentiated Carcinoma, the CpG Island Methylator Phenotype, and Adverse Prognosis in Microsatellite-unstable Colorectal Cancer
- Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal Cancer: Implications for Clinical and Pathology Practice
- CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer.
- Expression of intestine‐specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas
Cited by
- Prognostic impact of CDX2 in stage II colon cancer: results from two nationwide cohorts
- Fisher linear discriminant analysis for classification and prediction of genomic susceptibility to stomach and colorectal cancers based on six STR loci in a northern Chinese Han population
- Histopathological and Immunohistochemical Study of the Prognostic Significance of Cox2 and CDX2 Expression in the Available Cases of Colorectal Carcinoma
- Estimating the Economic Value of CDX2 as a Predictive Biomarker to Guide Treatment Decisions in Stage II Colon Cancer.
- Perturbations of Cytokine Interleukin-6 in Correlation with Cancer Stem Cell Markers in Oral Pre-Cancerous and Cancerous subjects
- Machine Learning–Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers
- CANDiT: A machine learning framework for differentiation therapy in colorectal cancer
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