Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD).
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Summary
Evidence supporting a key role for SREBPs in NAFLD is presented and it is suggested that further studies are urgently needed to evaluate modulation of SREBP activity as a potential new treatment forNAFLD.
- Type
- review
- Published
- 2007-09-01
- Cited by
- 177
- References
- 34
- OpenAlex
- https://openalex.org/W1998143374
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39721651
Keywords
Sterol regulatory element-binding protein, Fatty liver, Transcription factor, Peroxisome proliferator-activated receptor, Lipid metabolism
References
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- Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms.
- Long‐term follow‐up of patients with NAFLD and elevated liver enzymes
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- The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways*
- Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects
- The natural history of nonalcoholic fatty liver disease: a population-based cohort study.
- Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes*
- Hepatic glucose metabolism in humans--its role in health and disease.
- Biochemical markers: the road map for the diagnosis of nonalcoholic fatty liver disease.
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- A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
- Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦
- Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.
- Insig-1 “brakes” lipogenesis in adipocytes and inhibits differentiation of preadipocytes
- Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
- Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes.
- A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.
- Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.
Cited by
- RETRACTED: Reversion of hepatic steatosis by exercise training in obese mice: the role of sterol regulatory element-binding protein-1c.
- Identification and validation co-differentially expressed genes with NAFLD and insulin resistance
- Deletions of Fstl3 and/or Fst Isoforms 303 and 315 Results in Hepatic Steatosis
- JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis.
- Efeito dos óleos de coco e cártamo na adiposidade abdominal e perfil lipídico de ratas realimentadas com frutose
- Longitudinal evaluation of hepatic lipid deposition and composition in ob/ob and ob/+ control mice
- Die Regulation des Transkriptionsfaktors Carbohydrate Responsive Element Binding Protein (ChREBP) in Hep G2-Zellen
- Vitamin D attenuates high fat diet–induced hepatic steatosis in rats by modulating lipid metabolism
- Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet.
- Lycium ruthenicum extract alleviates high-fat diet-induced nonalcoholic fatty liver disease via enhancing the AMPK signaling pathway.
- Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling
- Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice.
- The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome
- Isoquercitrin activates the AMP–activated protein kinase (AMPK) signal pathway in rat H4IIE cells
- Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway.
- The potential role of prebiotic fibre for treatment and management of non‐alcoholic fatty liver disease and associated obesity and insulin resistance
- The Relationship between Nonalcoholic Fatty Liver Disease and Colorectal Cancer: The Future Challenges and Outcomes of the Metabolic Syndrome
- Ezetimibe as a potential treatment for non-alcoholic fatty liver disease: is the intestine a modulator of hepatic insulin sensitivity and hepatic fat accumulation?
- Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats.
- Hepatic Effects of a Methionine-Choline-Deficient Diet in Hepatocyte RXRα-null Mice
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