A Member of the GAGE Family of Tumor Antigens is an Anti-Apoptotic Gene that Confers Resistance to Fas/CD95/APO-1, Interferon-g, Taxol and g-irradiation
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Summary
Overall, the data establishes a functional link between GAGE-7C and two aspects of human tumor progression; namely, resistance to Fas induced apoptosis and to chemo- and radio- therapy.
- Type
- article
- Published
- 2002-05-09
- Cited by
- 103
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1997174909
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46435981
Keywords
Apoptosis, HeLa, Fas receptor, Transfection, Cancer research
References
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- KILLER/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death.
- Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.
- Dysregulation of apoptosis in cancer.
- Identification on a human sarcoma of two new genes with tumor-specific expression.
- A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines.
- PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.
- Two CD95 (APO‐1/Fas) signaling pathways
- Tumor radiosensitivity and apoptosis.
- Apoptosis regulators and their role in tumorigenesis.
- MAGE, BAGE, and GAGE gene expression in patients with esophageal squamous cell carcinoma and adenocarcinoma of the gastric cardia
- Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens.
- Control of the cell cycle and apoptosis.
- Paclitaxel‐induced cell death
- A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening.
- Escaping cell death: survival proteins in cancer.
- Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation.
- Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.
- Molecular effects of paclitaxel: Myths and reality (a critical review)
Cited by
- Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma
- Distinct GAGE and MAGE-A expression during early human development indicate specific roles in lineage differentiation.
- An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients
- Configuration and rearrangement of the human GAGE gene clusters.
- The Effect of Topical Estriol on Human Inner Foreskin
- Understanding the mechanism of cure in testicular cancer
- Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4. A novel strategy to reveal glioblastoma to the immune system
- GAGE12 mediates human gastric carcinoma growth and metastasis
- Understanding acquired resistance to Lapatinib in breast cancer cells
- Strategies for exploiting the immune system to achieve prevention and improve therapy of cancer
- Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy. Laboratory investigation.
- Loss of Bloom syndrome protein causes destabilization of genomic architecture and is complemented by ectopic expression of Escherichia coli Recg in human cells
- Production d'un peptide antigénique par l'insulin-degrading enzyme
- DNA hypomethylation and activation of germline-specific genes in cancer.
- Oncogenic cancer/testis antigens: prime candidates for immunotherapy
- Longitudinale Untersuchung der Expression von Cancer/Testis-Antigenen im Knochenmark von Patienten mit Multiplem Myelom
- Association of polymorphisms at HORMAD2 and prognosis in advanced non-small-cell lung cancer patients.
- Increased structural disorder of proteins encoded on human sex chromosomes.
- An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members.
- Longitudinal Analysis and Prognostic Effect of Cancer-Testis Antigen Expression in Multiple Myeloma
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