Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
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Summary
The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
- Type
- review
- Published
- 2006-12-01
- Cited by
- 4,065
- References
- 42
- OpenAlex
- https://openalex.org/W1997152791
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22384207
Keywords
Antimicrobial peptides, Antimicrobial, Innate immune system, Antibiotics, Protease
References
- Experimental evolution of resistance to an antimicrobial peptide
- Antibiotics: Non-haemolytic β-amino-acid oligomers
- Can innate immunity be enhanced to treat microbial infections?
- Cationic peptides: a new source of antibiotics.
- Peptoids as source of compounds eliciting antibacterial activity.
- Lipid II as a target for antibiotics
- Alarmins: chemotactic activators of immune responses.
- Structural congruence among membrane-active host defense polypeptides of diverse phylogeny.
- Mammalian defensins: structures and mechanism of antibiotic activity
- Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity
- Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
- The Human Antimicrobial Peptide LL-37 Transfers Extracellular DNA Plasmid to the Nuclear Compartment of Mammalian Cells via Lipid Rafts and Proteoglycan-dependent Endocytosis*
- Design of host defence peptides for antimicrobial and immunity enhancing activities.
- Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus
- Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments
- Therapeutic potential of the
- The co-evolution of host cationic antimicrobial peptides and microbial resistance
- Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes.
- Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I.
- Antimicrobial peptides: therapeutic potential
Cited by
- Induction by Cationic Antimicrobial Peptides and Involvement in Intrinsic Polymyxin and Antimicrobial Peptide Resistance, Biofilm Formation, and Swarming Motility of PsrA in Pseudomonas aeruginosa
- Human beta‐defensin‐3 promotes wound healing in infected diabetic wounds
- Protein epitope mimetics as anti-infectives.
- Biodegradable nanostructures with selective lysis of microbial membranes.
- Peptoids: bio-inspired polymers as potential pharmaceuticals.
- Investigation of the Staphylococcus aureus GraSR Regulon Reveals Novel Links to Virulence, Stress Response and Cell Wall Signal Transduction Pathways
- Initial Insights into Structure-Activity Relationships of Avian Defensins*
- Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus.
- Molecular characterization and expression of a novel big defensin (Sb-BDef1) from ark shell, Scapharca broughtonii.
- De novo cyclic pseudopeptides containing aza-β3-amino acids exhibiting antimicrobial activities.
- Host defense peptides: An alternative as antiinfective and immunomodulatory therapeutics
- What is the role of antimicrobial peptides (AMP) in acne vulgaris?
- Antifungal Activity of the Noncytotoxic Human Peptide Hepcidin 20 against Fluconazole-Resistant Candida glabrata in Human Vaginal Fluid
- De novo generation of short antimicrobial peptides with enhanced stability and cell specificity.
- Antimicrobial functionalization of silicone surfaces with engineered short peptides having broad spectrum antimicrobial and salt-resistant properties.
- Production of cecropin A antimicrobial peptide in rice seed endosperm
- Design and recombination expression of a novel plectasin-derived peptide MP1106 and its properties against Staphylococcus aureus
- Osmoprotective polymer additives attenuate the membrane pore‐forming activity of antimicrobial peptoids
- Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of α-helix-based peptide amphiphiles.
- d-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions
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