De novo generation of short antimicrobial peptides with enhanced stability and cell specificity.
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Summary
This study suggests that GNU6 and GNU7 might overcome serious problems that currently prevent the clinical use of AMPs and be developed as novel antimicrobial agents.
- Type
- article
- Published
- 2014-01-01
- Cited by
- 209
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W23946320
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22882603
Keywords
Art, Humanities, Lava, Volcano, Geology
References
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- Helix Stability Confers Salt Resistance upon Helical Antimicrobial Peptides*
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- Host-defense peptides: from biology to therapeutic strategies
- Diversity of antimicrobial peptides and their mechanisms of action.
- Bacterial resistance mechanisms against host defense peptides
- Magainins as paradigm for the mode of action of pore forming polypeptides.
- Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections.
- Computed circular dichroism spectra for the evaluation of protein conformation.
- Novel therapies based on cationic antimicrobial peptides.
- Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria.
- Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections
- Antimicrobial Activity of a Halocidin-Derived Peptide Resistant to Attacks by Proteases
Cited by
- AmyI-1-18, a cationic α-helical antimicrobial octadecapeptide derived from α-amylase in rice, inhibits the translation and folding processes in a protein synthesis system.
- Activity of Novel Synthetic Peptides against Candida albicans
- Activity of a novel‐designed antimicrobial peptide and its interaction with lipids
- Efficacy of the designer antimicrobial peptide SHAP1 in wound healing and wound infection
- Sonochemically processed cationic nanocapsules: efficient antimicrobials with membrane disturbing capacity.
- In Vitro and In Vivo Activities of Antimicrobial Peptides Developed Using an Amino Acid-Based Activity Prediction Method
- Host defense peptides: front-line immunomodulators.
- Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials.
- Potent Activities of Roemerine against Candida albicans and the Underlying Mechanisms
- Improved burn wound healing by the antimicrobial peptide LLKKK18 released from conjugates with dextrin embedded in a carbopol gel.
- Antimicrobial peptides: therapeutic potentials
- Strategies to stabilize cell penetrating peptides for in vivo applications.
- Screening for antibacterial activity of 15-MER linear synthetic peptide PAM-6 against Pseudomonas aeruginosa
- Multifunctional Polyphenols- and Catecholamines-Based Self-Defensive Films for Health Care Applications.
- Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity
- Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability.
- Enhancement of the antimicrobial activity and selectivity of GNU7 against Gram-negative bacteria by fusion with LPS-targeting peptide.
- High specific selectivity and Membrane-Active Mechanism of the synthetic centrosymmetric α-helical peptides with Gly-Gly pairs
- Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment.
- Temporizin and Temporizin-1 Peptides as Novel Candidates for Eliminating Trypanosoma cruzi
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