Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
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Summary
Plectasin showed extremely low toxicity in mice, and cured them of experimental peritonitis and pneumonia caused by S. pneumoniae as efficaciously as vancomycin and penicillin, and suggests that the defensins of insects, molluscs and fungi arose from a common ancestral gene.
- Type
- article
- Published
- 2005-10-13
- Cited by
- 643
- References
- 49
- OpenAlex
- https://openalex.org/W2013674343
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4423851
Keywords
Biology, Microbiology, Antimicrobial, Antimicrobial peptides, Antibiotics
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- Solution structure of drosomycin, the first inducible antifungal protein from insects
- Minidefensins and other antimicrobial peptides: candidate anti-HIV microbicides
- Antimicrobial peptides of multicellular organisms
- The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding.
Cited by
- High Cerebrospinal Fluid (CSF) Penetration and Potent Bactericidal Activity in CSF of NZ2114, a Novel Plectasin Variant, during Experimental Pneumococcal Meningitis
- Peptide antibiotics: an alternative and effective antimicrobial strategy to circumvent fungal infections.
- The defensin gene family expansion in the tick Ixodes scapularis.
- The Post-Antibiotic Era: Promising Developments in the Therapy of Infectious Diseases
- Design and recombination expression of a novel plectasin-derived peptide MP1106 and its properties against Staphylococcus aureus
- Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin*
- Yeast Expression Systems: Overview and Recent Advances
- A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms
- Internalization, distribution, and activity of peptide H2 against the intracellular multidrug-resistant bovine mastitis-causing bacterium Staphylococcus aureus
- Diversité moléculaire des effecteurs antimicrobiens chez l'huître creuse Crassostrea gigas : mise en évidence et rôle dans la réponse antimicrobienne
- Novel Endogenous Antimicrobial Peptides
- Host and Pathogen Sensory Systems as Targets for Therapeutic Intervention
- A biosynthetic approach to the discovery of novel bioactive peptides
- Etudes structurales de la défensine AhPDF1 de la plante Arabidopsis halleri impliquée dans la tolérance au zinc
- Katelicydyny i defensyny úwiæ
- Expression of plectasin in Bacillus subtilis using SUMO technology by a maltose-inducible vector
- Inhibition of cereal rust fungi by both class I and II defensins derived from the flowers of Nicotiana alata.
- Design of a Novel Antimicrobial Peptide Activated by Virulent Proteases
- Biopolimery w konstrukcji nowoczesnych materiałów medycznych o aktywności antydrobnoustrojowej. Cz. II. Metody aktywacji antydrobnoustrojowej materiałów medycznych
- α‐Defensins in human innate immunity
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