High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.

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Summary

Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.

Type
article
Published
1993-03-26
Cited by
2,040
References
61

Keywords

Vasculogenesis, Biology, Angiogenesis, In situ hybridization, Yolk sac

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