High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
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Summary
Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.
- Type
- article
- Published
- 1993-03-26
- Cited by
- 2,040
- References
- 61
- OpenAlex
- https://openalex.org/W2003598961
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46110063
Keywords
Vasculogenesis, Biology, Angiogenesis, In situ hybridization, Yolk sac
References
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- Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
- Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.
- Inducible expression of an endothelial cell antigen on murine myocardial vasculature in association with interstitial cellular infiltration.
- Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor.
- Signal transmission by the insulin-like growth factors.
- Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
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- Vascular endothelial growth factor confers a growth advantage in vitro and in vivo to stromal cells cultured from neonatal hemangiomas.
- Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
- Expression of Vascular Endothelial Growth Factor-A and its Receptors in Uteroplacental Tissues of the Normotensive and Hypertensive Pregnant Rat
- Vascular endothelial growth factor expression in canine peripheral vein bypass grafts.
- Therapeutic Angiogenesis: A New Frontier for Vascular Therapy
- Vascular endothelial growth factor (VEGF) expression during arterial repair in the pig.
- In vitro release of vascular endothelial growth factor during platelet aggregation.
- Vascular endothelial growth factor (VEGF)‐C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity
- Expression of angiogenic factors, basic fibroblast growth factor and vascular endothelial growth factor, in human biliary tract carcinoma cell lines.
- Vascular endothelial growth factor causally contributes to the angiogenic response upon ultraviolet B irradiation in vivo
- Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro.
- VEGF-RII Influences the Prognosis of Pancreatic Cancer
- Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
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- 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor.
- Hypoxia-inducible Factor and Vascular Endothelial Growth Factor Are Expressed More Frequently in Embolized than in Nonembolized Cerebral Arteriovenous Malformations
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