The transcription factor STAT3 is required for T helper 2 cell development

Keywords

Biology, Transcription factor, STAT3, Cancer research, Cell biology

References

• IL-4 regulates skin homeostasis and the predisposition towards allergic skin inflammationSarita Sehra, Yongxue Yao, Michael Howell — 2010
• Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1Anubhav Mathur, Hua-Chen Chang, Dimitrios G. Zisoulis — 2007
• IL-6 Plays a Unique Role in Initiating c-Maf Expression during Early Stage of CD4 T Cell Activation1Yang Yu, Jordi Ochando, Adam C. Yopp — 2005
• Expression of a Constitutively Active Stat6 In Vivo Alters Lymphocyte Homeostasis with Distinct Effects in T and B Cells1Heather A. Bruns, Ulrike Schindler, Mark H. Kaplan — 2003
• BATF Transgenic Mice Reveal a Role for Activator Protein-1 in NKT Cell Development1Kristi L. Williams, Alfred J. Zullo, Mark H. Kaplan — 2003
• IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1Matthew A. Burchill, Jianying Yang, Christine Vogtenhuber — 2007
• IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.Shlomo Z. Ben‐Sasson, Graham Le Gros, Daniel H. Conrad — 1990
• IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6Sarita Sehra, Heather A. Bruns, Ayele-Nati N. Ahyi — 2008
• CD4 T cells: fates, functions, and faults.Jinfang Zhu, William E. Paul — 2008
• Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and HomeostasisLydia Durant, Wendy T. Watford, Haydeé L. Ramos — 2010
• Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cellsWilliam E. Thierfelder, Jan M. van Deursen, Koh Yamamoto — 1996
• Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cellsJohn T. O’Malley, Sarita Sehra, Vivian T. Thieu — 2009
• T helper cell differentiation: regulation by cis elements and epigenetics.Gap Ryol Lee, Sean Kim, Charalampos G. Spilianakis — 2006
• Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineagesRoza Nurieva, Yeonseok Chung, Daehee Hwang — 2008
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Heon Park, Zhaoxia Li, Xuexian O. Yang — 2005
• Interleukin 2 plays a central role in Th2 differentiation.Javier Cote-Sierra, Gilles Foucras, Liying Guo — 2004
• Essential role of Stat6 in IL-4 signallingKiyoshi Takeda, Takashi Tanaka, Wei Shi — 1996
• Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 geneKazuya Shimoda, Jan van Deursent, Mark Y. Sangster — 1996
• Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic targetRoberto Chiarle, William J. Simmons, Honjying Cai — 2005
• T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cellsAndre A. Lighvani, David M. Frucht, Dragana Janković — 2001

Cited by

• The capacity of Th2 lymphocytes to deliver B‐cell help requires expression of the transcription factor STAT3N. I. Zhil'tsov, V. A. Ershov, И. В. Гончаров — 2013
• Early in vivo signaling profiles in MUC1-specific CD4+ T cells responding to two different MUC1-targeting vaccines in two different microenvironmentsEnrique Lynch — 2013
• Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNAR. Pinker, Juan José Bacallado Aránega — 2016
• Analyse des variantes d'épissage de l'Interleukine-4 dans l'étude de la réponse immunitaireCaroline Hauvespre — 2012
• The effects of host response and vaccine design on early signaling profiles of MUC1-specific T cellsDawn K. Reichenbach — 2013
• System-wide approaches to uncover Th2 cell lineage commitmentTapio Lönnberg — 2012
• Transcriptional and Epigenetic Regulation of Human CD4+ T Helper Lineage SpecificationS. Tripathi — 2014
• Serum levels of suppressor of cytokine signaling 3 and signal transducer and activator of transcription 3 in childhood atopic dermatitisYa-Ni Lyu, Lili Zhu, Ruiqun Qi — 2014
• Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A DissertationTia Bumpus Brodeur — 2014
• Twist1 and Etv5 are part of a transcription factor network defining T helper cell identityDuy Pham — 2013
• Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6Deepali V. Sawant — 2012
• Transcription factors in the development of Th9 cellsRitobrata Goswami — 2012
• E3 Ligases in T Helper 2-mediated PathogenesisAnupama Sahoo — 2014
• STAT6-dependent and -independent mechanisms in Th2 polarizationElisabeth Maier, Albert Duschl, Jutta Horejs‐Hoeck — 2012
• T-Zell Polarisierung bei der humanen Tuberkulose: Charakterisierung der Rolle von Suppressor of Cytokine Signaling (SOCS)-3 bei der Aktivierung und Differenzierung von CD4+ T-Zellen.Katja Kleinsteuber — 2012
• IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigensEugenio Gallo, Shoshana D. Katzman, Alejandro V. Villarino — 2012
• Decreased STAT5 phosphorylation and GATA-3 expression in NOX2 deficient T cells: Role in T helper developmentKristen E. Shatynski, Haiyan Chen, Jaeyul Kwon — 2012
• Differentiation, regulation and function of Th9 cells.Lei Jia, Changyou Wu — 2014
• Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.Jonathan M. Coquet, Martijn J. Schuijs, Mark J. Smyth — 2015
• Development and stability of IL-17-secreting T cellsNicole L. Glosson — 2014

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