CD4 T cells: fates, functions, and faults.
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Summary
Much of what is known about the 4 CD4 T-cell subsets is summarized, including the history of their discovery, their unique cytokine products and related functions, their distinctive expression of cell surface receptors and their characteristic transcription factors, the regulation of their fate determination, and the consequences of their abnormal activation.
- Type
- review
- Published
- 2008-09-01
- Cited by
- 1,869
- References
- 192
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965734808
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:369765
Keywords
Cytokine, Biology, Cell biology, Transcription factor, Cellular differentiation
References
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- IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
- X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
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- A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
- Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells1
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- Deletion of a coordinate regulator of type 2 cytokine expression in mice
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
- Stat6 Is Necessary and Sufficient for IL-4’s Role in Th2 Differentiation and Cell Expansion
- Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells.
- IL-4 directs the development of Th2-like helper effectors.
- Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.
- Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells
Cited by
- Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation.
- Epigenetic changes in inflammatory and autoimmune diseases.
- [CCR4, HTLV-1 infection, and ATL oncogenesis].
- Advances in single-cell experimental design made possible by automated imaging platforms with feedback through segmentation.
- Dose-Dependent Immunomodulation of Human Dendritic Cells by the Probiotic Lactobacillus rhamnosus Lcr35
- Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4+ T cells into specific lineage effector cells
- Analysis of IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV-coinfected patients
- Gene-environment interactions in asthma and allergic diseases: challenges and perspectives.
- T helper Cytokines in Dry Eye Disease
- Increased subsequent risk of myasthenia gravis in children with allergic diseases.
- Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice
- Correlation between IL-17A/F, IL-23, IL-35 and IL-12/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet’s patients
- Potent Antagonists of RORγt, Cardenolides from Calotropis gigantea, Exhibit Discrepant Effects on the Differentiation of T Lymphocyte Subsets.
- Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses
- The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation
- Mathematical modelling of T cell homeostasis
- Modulations nutritionnelles de la réponse à l'infection pulmonaire à P. aeruginosa dans différents fonds génétiques murins
- Role of Interleukin 21 in CD4 T cell regulation
- Cytokine Expression in the Cervical Stroma of HIV-Positive and HIV-Negative Women with Cervical Intraepithelial Neoplasia
- Characterization of the immune response induced by non-pathogenic mycobacteria in macrophages and dendritic cells
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