Detection of DNA mismatch repair (MMR) deficiencies by immunohistochemistry can effectively diagnose the microsatellite instability (MSI) phenotype in endometrial carcinomas.
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Summary
The equivalence of MSI testing and MMR IHC is shown, enabling stratification of cases for future clinical trials as well as assisting identification of Lynch syndrome, so that screening and risk reducing interventions can be undertaken.
- Type
- article
- Published
- 2015-05-01
- Cited by
- 201
- References
- 39
- OpenAlex
- https://openalex.org/W1995795701
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38528635
Keywords
Microsatellite instability, MSH2, Lynch syndrome, PMS2, Concordance
References
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- Interpretation of Immunohistochemistry for Mismatch Repair Proteins is Only Reliable in a Specialized Setting
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- MMR deficiency is common in high-grade endometrioid carcinomas and is associated with an unfavorable outcome.
- Association of Tumor Morphology With Mismatch-repair Protein Status in Older Endometrial Cancer Patients: Implications for Universal Versus Selective Screening Strategies for Lynch Syndrome
- Value of Immunohistochemical Detection of DNA Mismatch Repair Proteins in Predicting Germline Mutation in Hereditary Colorectal Neoplasms
- Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men: A Sex-Specific Meta-Analysis of Randomized Controlled Trials
- The multifaceted mismatch-repair system
- The utility of immunohistochemical detection of DNA mismatch repair gene proteins
- Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients
- Differences and evolution of the methods for the assessment of microsatellite instability
Cited by
- A clinically applicable molecular-based classification for endometrial cancers
- Availability and scope of integrated screening for patients with Lynch syndrome
- Molecular analysis of mixed endometrial carcinomas shows clonality in most cases
- Histopathological features of endometrial carcinomas associated with POLE mutations: implications for decisions about adjuvant therapy
- Lynch Syndrome Screening in the Gynecologic Tract: Current State of the Art
- Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts
- Loss of Mismatch Repair Protein Expression in Unselected Endometrial Adenocarcinoma Precursor Lesions
- Mismatch repair deficiency testing in clinical practice
- Lynch Syndrome: Female Genital Tract Cancer Diagnosis and Screening.
- Endometrial cancer: Not your grandmother's cancer
- Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: earlier prognostic information to guide treatment
- Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade.
- Microsatellite instability is associated with reduced disease specific survival in stage III colon cancer.
- Altered expression of the mismatch repair genes in DF-1 cells infected with the avian leukosis virus subgroup A
- Practical guidance for mismatch repair-deficiency testing in endometrial cancer
- Differences in Microsatellite Instability Profiles between Endometrioid and Colorectal Cancers: A Potential Cause for False-Negative Results?
- Genomic insights in gynecologic cancer.
- Microcystic, elongated, and fragmented pattern invasion is mainly associated with isolated tumor cell pattern metastases in International Federation of Gynecology and Obstetrics grade I endometrioid endometrial cancer.
- New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care
- The changing landscape of gynaecological cancer diagnosis: implications for histopathological practice in the 21st century
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