Agrin is highly expressed by chondrocytes and is required for normal growth
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Summary
It is shown for the first time that agrin is highly expressed by chondrocytes and localizes to the growth plate in wild-type mice, and that it plays a critical role in normal skeletal growth.
- Type
- article
- Published
- 2007-03-07
- Cited by
- 32
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W17186266
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2053651
Keywords
Humanities, Art, Political science, Art history
References
- A modification of the masson trichrome technique for routine laboratory purposes.
- Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
- Localization and alternative splicing of agrin mRNA in adult rat brain: transcripts encoding isoforms that aggregate acetylcholine receptors are not restricted to cholinergic regions
- Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis.
- Physiological Regulation of the Immunological Synapse by Agrin
- Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3
- Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.
- Kinetic studies on epiphyseal growth cartilage in the normal mouse.
- Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9.
- Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
- Muscle-derived agrin in cultured myotubes: expression in the basal lamina and at induced acetylcholine receptor clusters.
- Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity.
- C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling.
- Growth Plate Compressions and Altered Hematopoiesis in Collagen X Null Mice
- Synapse formation by hippocampal neurons from agrin-deficient mice.
- The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases.
- Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia
- Developmental regulation of the growth plate
- Defective neuromuscular synaptogenesis in agrin-deficient mutant mice.
- Expression of mouse agrin in normal, denervated and dystrophic muscle.
Cited by
- Exploring the role of agrin in skeletal muscle growth
- Exploration of neuromuscular plasticity: an examination of acetylcholine receptor and skeletal muscle fiber adaptations
- Recent progress in histochemistry
- Heparan Sulfate Proteoglycans: A GAGgle of Skeletal-Hematopoietic Regulators
- The Lens Capsule
- Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans
- Synapse Loss in Cortex of Agrin-Deficient Mice after Genetic Rescue of Perinatal Death
- Agrin and neuregulin, expanding roles and implications for therapeutics.
- Heparan sulfate proteoglycans in healthy and diseased systems
- Agrin in the nervous system: synaptogenesis and beyond
- New role for Agrin in T cells and its potential importance in immune system regulation
- Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function*
- The Basement Membrane Proteoglycans Perlecan and Agrin: Something Old, Something New.
- Stress Relaxation of Growth Plate Tissue under Uniform Compressive Load : Relationship Between Mechanical Response and Extracellular Matrix Bio-Composition and Structure
- Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
- Heparan sulfate proteoglycans as key regulators of the mesenchymal niche of hematopoietic stem cells
- Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice
- Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
- Pathogenic effects of agrin V1727F mutation are isoform-specific and decrease its expression and affinity for HSPGs and LRP4.
- Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers