Targeting the Nrf2 pathway against cardiovascular disease
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Summary
The current literature that suggests that Nrf2 is a valuable therapeutic target for cardiovascular disease is reviewed, as well as experiments that illustrate the mechanisms of NRF2 cardioprotection.
- Type
- article
- Published
- 2009-06-17
- Cited by
- 179
- References
- 105
- OpenAlex
- https://openalex.org/W19530984
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24183803
Keywords
Art, Humanities
References
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- Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
- Dithiolethiones for Cancer Chemoprevention: Where Do We Stand?
- Long range interaction of cis‐DNA elements mediated by architectural transcription factor Bach1
- Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.
- Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
- Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.
- Multivalent DNA Binding Complex Generated by Small Maf and Bach1 as a Possible Biochemical Basis for β-Globin Locus Control Region Complex*
- Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth In Vitro and Reduces Oxidative Stress in Rabbit Aorta In Vivo
- Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
- The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
- Heme Oxygenase-1 Inhibits Angiotensin II–Induced Cardiac Hypertrophy In Vitro and In Vivo
- Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation
- Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.
- Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothelium.
- Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress*
- Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
- Role of the Nrf2-Mediated Signaling Pathway as a Negative Regulator of Inflammation: Implications for the Impact of Particulate Pollutants on Asthma
Cited by
- Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
- Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice
- LOW REACTIVE OXYGEN SPECIES AND HIGH GLYCOLYSIS IN GLIOBLASTOMA STEM CELLS:MECHANISMS AND THERAPEUTIC IMPLICATIONS
- Mechanisms by which natural polyphenols regulate the expression of cytoprotective genes
- Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
- Antioxidants in Cardiovascular Therapy: Panacea or False Hope?
- Nitric Oxide, Oxidative Stress, and p66Shc Interplay in Diabetic Endothelial Dysfunction
- The Nrf2‐ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene‐Induced HTR cells damages in vitro
- Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression via the nuclear factor erythroid 2-related factor 2-antioxidant response element signaling pathway in human endothelial cells.
- Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
- The naked mole-rat as an animal model in biomedical research: current perspectives
- Role of Nrf2 in the pathogenesis of atherosclerosis.
- Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
- Cardioprotective Effect of Paeonol and Danshensu Combination on Isoproterenol-Induced Myocardial Injury in Rats
- The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel
- Icariside II Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression Coupled with the ERK, Akt and JNK Signaling Pathways
- Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?
- Extracellular Redox State Regulates Catecholamine Biosynthesis in PC12 Cells with Insulin Resistance
- Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2)*
- An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes
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