A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
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Summary
A potent, nonsteroidal FXR ligand is used to show that FXR induces expression of small heterodimer partner 1 (SHP-1), an atypical member of the nuclear receptor family that lacks a DNA-binding domain that provides a molecular basis for the coordinate suppression of CYP7A1 and other genes involved in bile acid biosynthesis.
- Type
- article
- Published
- 2000-09-01
- Cited by
- 1,915
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W1990819179
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13917561
Keywords
Farnesoid X receptor, Small heterodimer partner, Cholesterol 7 alpha-hydroxylase, G protein-coupled bile acid receptor, Biology
References
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Cited by
- New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor
- LuXuRies of lipid homeostasis: the unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing.
- Molecular mechanism for the potentiation of the transcriptional activity of human liver receptor homolog 1 by steroid receptor coactivator-1.
- Klotho and βKlotho.
- Differential regulation of glucocorticoid synthesis in murine intestinal epithelial versus adrenocortical cell lines.
- Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317 Published, JLR Papers in Press, September 6, 2007.
- Bile acids and signal transduction: role in glucose homeostasis.
- The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1
- Reduction in bile acid pool causes delayed liver regeneration accompanied by down-regulated expression of FXR and c-Jun mRNA in rats
- Bile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor α.
- Ligand-independent actions of the orphan receptors/corepressors DAX-1 and SHP in metabolism, reproduction and disease.
- Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters.
- The Role of Small Heterodimer Partner (SHP) in NAFLD Improvement after Vertical Sleeve Gastrectomy in Mice
- Elevated copper impairs hepatic nuclear receptor function in Wilson's disease.
- Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity
- 16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters.
- β-CATENIN REGULATION OF FARNESOID X RECEPTOR SIGNALING AND BILE ACID METABOLISM DURING MURINE CHOLESTASIS
- Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
- Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.
- Cholecystectomy and risk of metabolic syndrome
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