Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP.

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Summary

Recent studies show there is an "FXR/SHP-independent" mechanism that also represses CYP7A1 expression, which involves the interaction of bile acids with liver macrophages, which induces the expression, and secretion of cytokines.

Type
article
Published
2002-04-01
Cited by
78
References
0
Access
Open access

Keywords

Cholesterol 7 alpha-hydroxylase, Farnesoid X receptor, Small heterodimer partner, G protein-coupled bile acid receptor, Bile acid

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