TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus
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Summary
DNA methylation, and particularly 5hmC, may be involved in regulating TREM2 mRNA expression in the AD brain and further studies are guaranteed to investigate in depth the role of 5hmC in AD and other neurodegenerative disorders.
- Type
- article
- Published
- 2016-04-05
- Cited by
- 85
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W27051467
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10790937
Keywords
Geography
References
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- Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease
- Regulation of TREM2 expression by an NF-κB-sensitive miRNA-34a
- 5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models.
- TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model
- Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction
- Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.
- The Triggering Receptor Expressed on Myeloid Cells 2: “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease
- A Role for TREM2 Ligands in the Phagocytosis of Apoptotic Neuronal Cells by Microglia
Cited by
- Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer’s disease brain
- TREMs in Alzheimer's disease: Genetic and clinical investigations.
- Opening up the DNA methylome of dementia
- The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review
- Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer’s disease
- DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.
- Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
- DNA Methylation Changes in Intron 1 of Triggering Receptor Expressed on Myeloid Cell 2 in Japanese Schizophrenia Subjects
- Epigenetic Modification of mitochondrial genes in Alzheimer's disease (AD)
- TREM2 in Neurodegenerative Diseases
- Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
- Soluble TREM2 and Biomarkers of Central and Peripheral Inflammation in Neurodegenerative Disease
- Peripheral DNA methylation, cognitive decline and brain aging: pilot findings from the Whitehall II imaging study
- Could Alzheimer’s Disease Originate in the Periphery and If So How So?
- Role of epigenetics in Alzheimer's disease pathogenesis.
- Epigenetic characterisation of ANK1, a novel gene implicated in Alzheimer’s disease (AD)
- PLD3 epigenetic changes in the hippocampus of Alzheimer’s disease
- New insights into the role of TREM2 in Alzheimer’s disease
- Hippocampal LMNA Gene Expression is Increased in Late-Stage Alzheimer’s Disease
- TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
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