Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay
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Summary
The finding of widespread methylation of homeobox genes lends support to the hypothesis that a substantial fraction of genes methylated in human cancer are targets of the Polycomb complex.
- Type
- article
- Published
- 2007-03-27
- Cited by
- 296
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W1989578834
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23090221
Keywords
Biology, Methylation, DNA methylation, Homeobox, CpG site
References
- CpG island methylator phenotype in cancer
- HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.
- X inactivation, differentiation, and DNA methylation.
- Compromised HOXA5 function can limit p53 expression in human breast tumours
- Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
- The fundamental role of epigenetic events in cancer
- Maintenance of functional equivalence during paralogous Hox gene evolution
- A gene hypermethylation profile of human cancer.
- Early detection: The power and the promise of DNA methylation markers
- Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
- The genesis and evolution of homeobox gene clusters
- Global and Hox-specific roles for the MLL1 methyltransferase.
- Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
- Reversal of Hox1 gene subfunctionalization in the mouse.
- The polycomb group protein EZH2 is involved in progression of prostate cancer
- Detection and interpretation of altered methylation patterns in cancer cells
- Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer
- Epigenetics in human disease and prospects for epigenetic therapy
- SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
- A gene complex controlling segmentation in Drosophila
Cited by
- Biological signature of HER2-positive breast cancer
- High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.
- Epigenetic mechanisms and cancer: An interface between the environment and the genome
- Genome‐wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
- Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study
- DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons
- HOX proteins and leukemia.
- Methylated-CpG Island Recovery Assay
- Genetic and Epigenetic Profiling of Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia
- DNA-Methylierung als epigenetischer Regulator von fünf Genen im nicht-kleinzelligen Lungenkarzinom (NSCLC)
- Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
- Oncología clínica, genómica y epigenómica en cáncer broncogénico. Parte II
- The MIRA method for DNA methylation analysis
- Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis
- 生物芯片技术在肺癌研究中的应用价值
- HOXA11 hypermethylation is associated with progression of non-small cell lung cancer
- HOXA9 inhibits migration of lung cancer cells and its hypermethylation is associated with recurrence in non‐small cell lung cancer
- Epigenetic Changes During Cell Transformation
- DNA甲基化在肺癌早期诊断中的研究进展
- Methylated DNA Immunoprecipitation and Microarray-Based Analysis: Detection of DNA Methylation in Breast Cancer Cell Lines
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