Drug Addiction, Dysregulation of Reward, and Allostasis
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Summary
The view that addiction is the pathology that results from an allostatic mechanism using the circuits established for natural rewards provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and relapse.
- Type
- review
- Published
- 2001-02-01
- Cited by
- 2,857
- References
- 286
- Access
- Open access
- OpenAlex
- https://openalex.org/W1989416066
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3993014
Keywords
Allostasis, Addiction, Psychology, Neuroscience, Neurochemical
References
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- Relapse Prevention
- The lateral nucleus of the amygdala mediates expression of the amphetamine-produced conditioned place preference
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- Stress-induced sensitization and glucocorticoids. II. Sensitization of the increase in extracellular dopamine induced by cocaine depends on stress-induced corticosterone secretion
- Postcocaine anhedonia. An animal model of cocaine withdrawal.
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- Regulation of CRE‐mediated transcription in mouse brain by amphetamine
- Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens
- Ethanol consumption and serotonin‐1A (5‐HT1A) receptor function in heterozygous BDNF (+/–) mice
- Role of the Serotonergic System in Alcohol Dependence: From Animal Models to Clinics
- Genetic Determinants of Addiction to Opioids and Cocaine
- CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression.
- Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective review.
- Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case–control studies and evidence of publication bias
- Increased rewarding properties of morphine in perinatally protein-malnourished rats.
- Evidence for a role of endogenous neurotensin in the development of sensitization to the locomotor stimulant effect of morphine.
- Substance use disorders: realizing the promise of pharmacogenomics and personalized medicine.
- Descending Facilitatory Pathways From the Rostroventromedial Medulla Mediate Naloxone-precipitated Withdrawal in Morphine-Dependent Rats
- Editorial for International Journal of Behavioral Medicine: Special Issue on Cancer
- Effects of amphetamine on the human brain opioid system – a positron emission tomography study
- Gene Expression in the Addicted Brain
- A polyamine-deficient diet opposes hyperalgesia, tolerance and the increased anxiety-like behaviour associated with heroin withdrawal in rats.
- A Prospective Study of the Effects of the DRD2/ANKK1 TaqIA Polymorphism and Impulsivity on Smoking Initiation
- Dopaminergic involvement in effort-based but not impulsive reward processing in smokers.
- Decreased frontal N-acetylaspartate levels in adolescents concurrently using both methamphetamine and marijuana
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