Evidence for a role of endogenous neurotensin in the development of sensitization to the locomotor stimulant effect of morphine.
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Summary
It is suggested that endogenous neurotensin contributes to the acute locomotor stimulant effect of morphine and to the induction of its sensitization, a sensitization effect that was attenuated by SR-48692.
- Type
- article
- Published
- 2008-10-10
- Cited by
- 4
- References
- 50
- OpenAlex
- https://openalex.org/W2040162834
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31653833
Keywords
Neurotensin, Sensitization, Stimulant, Morphine, Locomotor activity
References
- Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization.
- Mediation by neurotensin‐receptors of effects of neurotensin on self‐stimulation of the medial prefrontal cortex
- Neurotensin: a new 'reward peptide'.
- Extensive co-localization of neurotensin with dopamine in rat meso-cortico-frontal dopaminergic neurons.
- Ventral pallidal injections of a mu antagonist block the development of behavioral sensitization to systemic morphine
- D-amphetamine-induced behavioral sensitization: effect of lesioning dopaminergic terminals in the medial prefrontal cortex, the amygdala and the entorhinal cortex.
- Drug Addiction, Dysregulation of Reward, and Allostasis
- SR 48692-sensitive neurotensin receptors modulate acetylcholine release in the rat striatum.
- Activation of neurotensin receptors in the prefrontal cortex stimulates midbrain dopamine cell firing.
- Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects.
- Sensitization occurs to the locomotor effects of morphine and the specific mu opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens.
- Repeated activation of neurotensin receptors sensitizes to the stimulant effect of amphetamine.
- Two transpallidal pathways originating in the rat nucleus accumbens
- μ‐Opioid receptors in the ventral tegmental area are targeted to presynaptically and directly modulate mesocortical projection neurons
- Electrophysiological effects of neurotensin on dopaminergic neurones of the ventral tegmental area of the rat in vitro.
- Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
- Tolerance and sensitization to the behavioral effects of drugs.
- Chronic Blockade of Neurotensin Receptors Strongly Reduces Sensitized, but Not Acute, Behavioral Response to D-amphetamine
- Involvement of cortical neurotensin in the regulation of rat meso‐cortico‐limbic dopamine neurons: Evidence from changes in the number of spontaneously active A10 cells after neurotensin receptor blockade
- SR 48692, a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission.
Cited by
- In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist
- Attenuating effect of adenosine receptor agonists on the development of behavioral sensitization induced by sporadic treatment with morphine.
- Neurotensin: A role in substance use disorder?
- The role of the L-arginine-NO-cGMP-dependent pathway in the development of sensitization to mephedrone effects on the locomotor activity in mice.
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