DNA damage checkpoints: from initiation to recovery or adaptation.

Keywords

Biology, DNA damage, G2-M DNA damage checkpoint, Context (archaeology), DNA repair

References

• Cell-cycle checkpoints and cancerMichael B. Kastan, Jiří Bártek — 2004
• Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damageLuca Busino, Maddalena Donzelli, Massimo Chiesa — 2003
• The pathological response to DNA damage does not contribute to p53-mediated tumour suppressionMaria A. Christophorou, Ingo Ringshausen, Andrew J. Finch — 2006
• Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.Xin Wang, Lee Zou, Tao Lu — 2006
• Regulation of G2/M events by Cdc25A through phosphorylation‐dependent modulation of its stabilityNiels Mailand, Alexandre V. Podtelejnikov, Anja Groth — 2002
• Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retentionClaudia Lukas, Fredrik Melander, Manuel Stucki — 2004
• Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.Akiko Kumagai, William G. Dunphy — 2000
• Checking on DNA damage in S phaseJiří Bártek, Claudia Lukas, Jiri Lukas — 2004
• Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damageClaudia Lukas, Jacob Falck, Jiřina Bártková — 2003
• Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complexKate E. Adams, Annette L. Medhurst, D. Alwyn Dart — 2006
• Initiating cellular stress responses.Christopher J. Bakkenist, Michael B. Kastan — 2004
• Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases.Randi G. Syljuåsen, Sanne Jensen, Jiří Bártek — 2006
• gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.Manuel Stucki, Stephen P. Jackson — 2006
• Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.Niels Mailand, Simon Bekker‐Jensen, Jiří Bártek — 2006
• ATM Activation in Normal Human Tissues and Testicular CancerJiřina Bártková, Christopher J. Bakkenist, Ewa Rajpert‐De Meyts — 2005
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationChristopher J. Bakkenist, Michael B. Kastan — 2003
• Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathwayYael Ziv, Dana Bielopolski, Yaron Galanty — 2006
• Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis.Frederic Tort, Jiřina Bártková, Maxwell Sehested — 2006
• MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.Manuel Stucki, Julie A. Clapperton, Duaa H. Mohammad — 2005
• Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivoManuela Pellegrini, Arkady Celeste, Simone Difilippantonio — 2006

Cited by

• The repair and signaling responses to DNA double-strand breaks.Aaron A. Goodarzi, Penelope A. Jeggo — 2013
• Checkpoint recovery after DNA damage: a rolling stop for CDKsKateřina Bartoníčková — 2010
• Accumulation of DNA Damage and Cell Death after Fractionated IrradiationPer Lagerfelt — 2011
• Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.Nor Arina Adam — 2011
• Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cellsJoão Quêndido Gomes Carvalho, José Augusto Vieira Costa — 2012
• Working hard for recovery: mitotic kinases in the DNA damage checkpointLilian Moncrieff — 2013
• The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles.Ying‐Nan Chiu — 2013
• FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLCTeruo Watanabe — 2015
• Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy史朗 中村 — 2015
• Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation.Daniel A. Birch — 2017
• Xanthatin triggers Chk1‐mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cellsKevin J. Breen, Andrew J. Gavin, R. R. Schnabel — 2017
• FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy.Inken Wierstra — 2013
• Histone modifications across the cell cycle in undifferentiated and differentiating mouse embryonic stem cellsHannah Myren Goss — 2014
• BRIT1/MCPH1 MEDIATES THE DNA DAMAGE RESPONSE BY INDUCING P53 STABILITY AND PROMOTING ATR SIGNALINGE. Wang — 2014
• A focus on foci: How spatio-temporal regulation of the DNA damage response is crucial for DDR activation and cell fateLeonie Kollenstart — 2014
• The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.Yue Chen, Randy Y.C. Poon — 2008
• Methods to study cancer therapeutic drugs that target cell cycle checkpoints.Yun Dai, Steven Grant — 2011
• The Regulation of Cellular Stress Resistance and DNA Repair in a Long-Lived Mutant Mouse.Adam B. Salmon — 2007
• Physiological aspects of UV-excitation of DNA.RICHA RICHA, Rajeshwar P. Sinha, Donat‐P. Häder — 2015
• DNA-Reparatur und AlterungBjörn Schumacher — 2012

Related papers

• Cell-cycle checkpoint kinases: checking in on the cell cycle.Nancy C. Walworth — 2000
• DNA damage checkpoints update: getting molecular.Ted Weinert — 1998
• Molecular Anatomy of the DNA Damage and Replication CheckpointsJun Qin, Lei Li — 2003
• Toward maintaining the genome: DNA damage and replication checkpoints.Kara A. Nyberg, Rhett J. Michelson, Charles W. Putnam — 2002
• Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1Katsunori Tanaka, Paul S. Russell — 2001
• Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.Nick Rhind, Paul Russell — 2000
• ATM-dependent cell-cycle arrest tamed in the test tubeJan de Boer — 2000
• Ensuring the Stability of the Genome: DNA Damage CheckpointsChristine Latif, Susan H. Harvey, Susan J. O'Connell — 2001
• Hypersensitivity to DNA damage in antephase as a safeguard for genome stabilityFemke M. Feringa, Lenno Krenning, André Koch — 2016