Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells.
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Summary
The results suggest that stimulation of 3T3 cells involves at least one obligatory actin-mediated step, andTransformed cells appear to obviate this step, for H2CB does not inhibit the entry into S phase of SV40- transformed or Moloney murine sarcoma virus-transformed 3T 3 cells synchronized by mitotic shake-off.
- Type
- article
- Published
- 1982-08-01
- Cited by
- 95
- References
- 29
- OpenAlex
- https://openalex.org/W1988159688
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11874987
Keywords
Biology, DNA synthesis, 3T3 cells, Cell biology, Microfilament
References
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Cited by
- Cell shape, the complex cellular networks, and gene expression. Cytoskeletal protein genes as a model system.
- Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27).
- Possible involvement of reorganization of actin filaments, induced by tumor‐promoting phorbol esters, in changes in colony shape and enhancement of proliferation of cultured epithelial cells
- Cell-cycle-specific and serum-dependent expression of gamma-actin mRNA in Swiss mouse 3T3 cells
- Small GTP-binding proteins and the regulation of the actin cytoskeleton.
- Disruption of actin microfilaments by cytochalasin D leads to activation of p53
- Role of immunoreceptor tyrosine-based activation motif in signal transduction from antigen and Fc receptors.
- Clostridium difficile cytotoxin inhibits protein synthesis in fibroblasts and intestinal mucosa.
- Studies of SV40-transformation and the Loss of Growth Factor Requirements
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- Differential control of cytokeratins and vimentin synthesis by cell- cell contact and cell spreading in cultured epithelial cells
- Cytoskeletal perturbation induced by herbicides, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T).
- Overexpression of H1 Calponin in Osteoblast Lineage Cells Leads to a Decrease in Bone Mass by Disrupting Osteoblast Function and Promoting Osteoclast Formation
- Cell shape‐dependent pathway of plasminogen activator inhibitor type‐1 gene expression requires cytoskeletal reorganization
- Cell-contact and-architecture of malignant cells and their relationship to metastasis
- Modulation of survival and proliferation of BSC-1 cells through changes in spreading behavior caused by the tumor-promoting phorbol ester TPA.
- Evidence for the potentiation of epidermal growth factor receptor tyrosine kinase activity by association with the detergent-insoluble cellular cytoskeleton: analysis of intact and carboxy-terminally truncated receptors.
- Effect of cytochalasins on surfactant release from alveolar type II cells.
- Inhibition by cytochalasin B of DNA synthesis in a thermosensitive anchorage‐independent growth mutant
- Ruffling and locomotion: Role in cell resistance to growth factor‐induced proliferation
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