An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes.

Keywords

Biology, Fusion gene, Homologous recombination, Chromosomal translocation, Chimeric gene

References

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Cited by

• Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.Tsukasa Okuda, Zhongling Cai, Shouli Yang — 1998
• dELL, a drosophila homologue of transcription elongation factor ELL (eleven‐nineteen lysine rich leukemia), is required for early development千秋 内田 — 2002
• Lymphoma‐ and leukemia‐associated chromosomal translocations in healthy individualsBirte Boelt — 2003
• Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.Elisabet Jansson, Helena Löfgren — 2003
• Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9.Marc Girard — 2003
• A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy.茂 奥山 — 2006
• Mouse Chromosome Engineering for Modeling Human DiseaseT.G.C. van Aken — 2006
• The relative fitness of hematopoietic progenitors influences leukemia progression恭子 鈴木, 寛大 木下, 和大 宮川 — 2011
• The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.Adelheid Bursen, Karen Schwabe, Brigitte Rüster — 2010
• Activation, Regulation and Transcription of the Human and Murine Globin Loci.M. Krom — 2002
• myeloid leukemia Biologic and clinical significance of the FLT3 transcript level in acuteKatsuji Shinagawa, Akihiro Takeshita, Ryuzo Ueda — 2013
• Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23).Kimihiko Sano, Akira Hayakawa, Jinhua Piao — 2000
• Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.Hideshi Yagi, Kenji Deguchi, Atsufumi Aono — 1998
• Mechanisms of MLL Fusion Protein-Mediated Leukemic TransformationSara Monroe — 2010
• A new cytokine-dependent monoblastic cell line with t(9;11)(p22;q23) differentiates to macrophages with macrophage colony-stimulating factor (M-CSF) and to osteoclast-like cells with M-CSF and interleukin-4.Takashi Ikeda, Kazunori Sasaki, Kazuma Ikeda — 1998
• The impact of biology on the treatment of secondary AML.Ivana Gojo, Judith E. Karp — 2001
• Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia.Carolyn A. Felix, Maureen D. Megonigal, David S. Chervinsky — 1998
• Studying the role of the fusion protein MLL-AF4 in leukemogenesis with the help of siRNAsEberhard Karls — 2007
• A model to investigate the oncogenic activity of MLL-fusions in Acute Myeloid LeukaemiaV. Walf-Voderwüelbecke — 2009
• Cell Memory and Cancer – The Story of the Trithorax and Polycomb Group GenesCarlos Caldas, Samuel Aparício — 2004

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