Hypusine-containing Protein eIF5A Promotes Translation Elongation
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Summary
Molecular genetic and biochemical studies are used to show that eIF5A promotes translation elongation, and suggest that it might function together with eEF2 to promote ribosomal translocation.
- Type
- article
- Published
- 2009-05-07
- Cited by
- 441
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1983788160
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4342822
Keywords
Protein biosynthesis, Puromycin, Polysome, Ribosome, Biology
References
- Temperature-sensitive eIF5A Mutant Accumulates Transcripts Targeted to the Nonsense-mediated Decay Pathway*
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- Regulation of protein synthesis in mammalian cells. II. Inhibition of protein synthesis at the level of initiation during mitosis.
- Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
- Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae.
- New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.
- Uninterrupted MCM2-7 function required for DNA replication fork progression.
- Crystal structure of elongation factor P from Thermus thermophilus HB8.
- Evidence for control of protein synthesis in HeLa cells via the elongation rate
- Is there a role for eIF5A in translation?
- Post-transcriptional regulation in higher eukaryotes: The role of the reporter gene in controlling expression
- Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification
- Functional Interactions between Yeast Translation Eukaryotic Elongation Factor (eEF) 1A and eEF3*
- Universally conserved translation initiation factors.
- Recessive nonsense‐suppression in yeast: further characterization of a defect in translation
Cited by
- Polyamines in cancer.
- Acetate reduces microglia inflammatory signaling in vitro
- Getting Past Polyproline Pauses
- Analysis of polysomes from bacteria.
- Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer
- In silico Design, Synthesis, and Screening of Novel Deoxyhypusine Synthase Inhibitors Targeting HIV‐1 Replication
- Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells
- Holophytochrome-Interacting Proteins in Physcomitrella: Putative Actors in Phytochrome Cytoplasmic Signaling
- Synthesis and Bioevaluation of Macrocycle-Polyamine Conjugates as Cell Migration Inhibitors.
- Eukaryotic initiation factor 5A and Ca2+/calmodulin‐dependent protein kinase 1D modulate trophoblast cell function
- Translation Elongation and Recoding in Eukaryotes
- Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast
- DISCOVERY AND CHARACTERIZATION OF THE INTERPHASE FUNCTION OF MITOTIC MOTORS IN PROTEIN SYNTHESIS
- Veränderungen der Wirtszellgenexpression in Keratinozyten durch karzinogene humanpathogene Papillomaviren
- The translation factor eIF5A and human cancer
- Maintenance of Protein Synthesis Reading Frame by EF-P and m1G37-tRNA
- Biological Relevance and Therapeutic Potential of the Hypusine Modification System*
- Discovery of conserved motifs in MARCO through evolutionary analyses and molecular biology
- Hypusination of Eukaryotic Initiation Factor 5A via cAMP-PKA-ERK1/2 Pathway is required for Ligand-induced Downregulation of LH receptor mRNA Expression in the Ovary
- Caracterização de mutantes condicionais do gene da desoxi-hipusina sintase em Saccharomyces cerevisiae
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