Pulvomycin, an inhibitor of protein biosynthesis preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA.

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Summary

Pulvomycin and the synonymous antibiotics labilomycinand 1063-Z are shown to inhibit prokaryotic protein synthesis by acting on elongation factor Tu (EF-Tu): in the presence of the antibiotic, the affinity of EF-Tu for guanine nucleotides is altered, and the formation of the EF- Tu.GTP complex is stimulated.

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article
Published
1978-11-01
Cited by
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Keywords

GTP', Aminoacyl-tRNA, EF-Tu, Ternary complex, Ribosome

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